Publications by authors named "Rodriguez-Martinez M"
Digital twins represent a key technology for precision health. Medical digital twins consist of computational models that represent the health state of individual patients over time, enabling optimal therapeutics and forecasting patient prognosis. Many health conditions involve the immune system, so it is crucial to include its key features when designing medical digital twins.
View Article and Find Full Text PDFTranscription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and transcription factor IIH (TFIIH) around lesion-stalled RNAPII. However, the mechanism and factors required for the transition to downstream repair steps, including RNAPII removal to provide repair proteins access to the DNA lesion, remain unclear.
View Article and Find Full Text PDFDeep Learning Methods to Help Predict Properties of Molecules from SMILES.
Proc Int Symp Intell Comput Netw 2024 (2024)
August 2024
Machine learning methods have been proposed in lieu of simulations to predict chemical properties of molecules. The trade-off here is paying for the training time once, in exchange for instant predictions on the input data. However, many of these methods rely heavily on feature engineering to prepare the data for these models.
View Article and Find Full Text PDFArcaDB: A Disaggregated Query Engine for Heterogenous Computational Environments.
IEEE Int Conf Cloud Comput
July 2024
Modern enterprises rely on data management systems to collect, store, and analyze vast amounts of data related to their operations. Nowadays, clusters and hardware accelerators (e.g.
View Article and Find Full Text PDFArticle Synopsis
- - RNA-sequencing has improved our knowledge of rheumatoid arthritis (RA), but there's still a lack of understanding about specific cell types and how they regulate the disease, particularly fibroblast-like synoviocytes (FLS).
- - This research identified 28 transcription factors (TFs) that regulate RA FLS, with BACH1 being the most significant; it plays a key role in fatty acid metabolism and ferroptosis, with six of these TFs being newly associated with RA.
- - BACH1's role was validated through experiments showing that knocking it down in RA FLS affected essential functions like cell adhesion and movement, highlighting its potential as a therapeutic target for RA.
Background: The development of haemophilic arthropathy causes joint damage that leads to functional impairment that limits the performance of activities in patients with haemophilia. The aim was to identify the best predictive model for performing instrumental activities of daily living in adult patients with haemophilia arthropathy.
Methods: Cross-sectional cohort study.
Article Synopsis
- Lung ultrasound could be a valuable tool in predicting the severity of lung disease and the need for extended ventilatory support in critically ill children.
- In a study involving 538 children in the ICU, those requiring prolonged mechanical ventilation (over 7 days) had significantly higher lung ultrasound scores at 12 and 48-72 hours post-admission.
- The lung ultrasound score demonstrated a strong correlation with oxygen levels and was effective in predicting prolonged mechanical ventilation, showing high accuracy in both initial assessment and multivariable analysis.
Early Occupational Therapy Intervention Programme and Coping Strategies and Burden in Caregivers of People with Sub-Acute Stroke: A Randomised Controlled Trial.
J Pers Med
August 2024
Article Synopsis
- Caregivers of stroke patients often face significant stress and may cope by disengaging from the situation.
- A study in Spain tested an early occupational therapy intervention (EOTIPS) to see if it could help both stroke patients and their caregivers during the transition from hospital to home.
- Results showed that caregivers who participated in EOTIPS reported a significant reduction in their burden and improved coping strategies, highlighting its potential as a valuable support tool.
Article Synopsis
- - Pediatric acute myeloid leukemia (AML) is a serious blood cancer with a high chance of returning after treatment, making it tough to target for immunotherapy due to varying cell types in patients.
- - Researchers developed a new computational tool that uses single-cell flow cytometry data from 21 pediatric AML patients to accurately identify cancerous cells and their developmental stages, achieving a classification accuracy of 90%.
- - The study found significant changes in the immunophenotypes of cancer cells between diagnosis and relapse, especially in patients with specific genetic alterations, providing insights that could help in designing more effective personalized treatments for AML.
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease affecting synovial tissues, but the specifics of the disease's regulatory mechanisms at the cellular level remain unclear.
- The study utilized RNA-seq databases to create a new method for identifying cell type-specific regulatory networks in RA, comparing these findings to osteoarthritis to uncover differences in gene regulation.
- Key regulatory factors were identified across various cell types in RA, revealing that fibroblast-like synoviocytes and B cells are influenced by multiple transcription factor clusters, while monocytes are primarily driven by a single cluster, hinting at potential new treatment targets for RA.
Article Synopsis
- Occupational therapy significantly aids stroke patients in regaining independence and improving their quality of life post-discharge.
- A study in Spain assessed the Early Occupational Therapy Intervention Program (EOTIPS) with 60 stroke patients, comparing outcomes between an experimental group receiving EOTIPS and a control group.
- Results showed that the EOTIPS group had improved quality of life, functional independence, cognitive skills, and lower depression symptoms compared to the control group.
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and TFIIH around lesion-stalled RNAPII. However, the mechanism and factors required for the transition to downstream repair steps, including RNAPII removal to provide repair proteins access to the DNA lesion, remain unclear.
View Article and Find Full Text PDFHyperlacticaemia in children with status asthmaticus. The Stewart approach.
Rev Esp Anestesiol Reanim (Engl Ed)
August 2024
Background: Patients with status asthmaticus (SA) frequently present with lactic acidosis (LA). Our goal is to identify the nature of this LA using the Stewart physicochemical model and to identify the independent factors associated with LA in children with SA.
Methods: Analytical study of a retrospective cohort using a nested case-control design.
Exploring the interplay of frailty, physical function, physical activity, nutritional status, and their association with quality of life and depressive symptoms in older adults with the frailty phenotype.
Int J Geriatr Psychiatry
March 2024
Article Synopsis
- The study investigates how frailty, physical function, activity levels, and nutrition affect the quality of life and depression in older adults.
- Conducted with 235 older adults in Spain, various assessments were used to evaluate frailty, physical function, activity, nutrition, and mental health.
- Key findings show that fatigue and slow walking speed negatively impact quality of life and increase depressive symptoms, while better nutrition and moderate physical activity act as protective factors.
Article Synopsis
- * Findings reveal that only 34.5% of youth meet physical activity recommendations, with varying participation in organized sports, active play, and sedentary behaviors, while girls are generally less active than boys.
- * Despite some positive parenting and school involvement in physical activity, significant gaps exist, highlighting the need for improved opportunities for movement among children in Mexico.
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation in synovial tissues, yet there is limited understanding of the key transcription factors (TFs) and regulatory networks involved.
- The study utilized existing RNA-seq data from RA synovial tissues to develop a new method for analyzing cell type-specific gene regulatory networks, comparing RA to osteoarthritis.
- Key findings revealed 18, 16, 19, and 11 important regulators for fibroblast-like synoviocytes, T cells, B cells, and monocytes, respectively, with distinct TF clusters driving FLS and B cell functions, while monocytes were influenced by a single driver cluster, potentially opening new avenues for RA treatment.
Development and Validation of a Highly Sensitive Multiplex Immunoassay for SARS-CoV-2 Humoral Response Monitorization: A Study of the Antibody Response in COVID-19 Patients with Different Clinical Profiles during the First and Second Waves in Cadiz, Spain.
Microorganisms
December 2023
Article Synopsis
- The COVID-19 pandemic continues to challenge healthcare systems with emerging waves, necessitating new preventive tools and therapies.
- A novel immunoassay using Bio-Plex technology has been developed to simultaneously detect multiple IgG antibodies against different SARS-CoV-2 antigens, showcasing high sensitivity and specificity.
- This multiplex immunoassay serves as a robust tool for monitoring humoral immunity and can aid in epidemiological surveillance, particularly in analyzing antibody responses among unvaccinated COVID-19 patients in Cadiz, Spain.
Article Synopsis
- * A scoping review aimed to explore the role of occupational therapy in managing haemophilia, highlighting its therapeutic potential.
- * No specific occupational therapy interventions for haemophilia were identified, but existing measurement tools and the need for multidisciplinary treatment underscore its importance for improving patients' autonomy and quality of life.
Proteomic-based stratification of intermediate-risk prostate cancer patients.
Life Sci Alliance
February 2024
Article Synopsis
- * A study analyzed 1,348 tumor and benign samples from 278 patients, identifying F5, TMEM126B, and EARS2 as potential biomarkers linked to biochemical recurrence.
- * An 18-protein risk score was developed to effectively categorize patients into low- and high-risk groups for biochemical recurrence, showing promise for improving prostate cancer management independent of Gleason grades.
Article Synopsis
- The review aims to evaluate the origins of tension headaches, considering both peripheral (outside the brain) and central (inside the brain) factors to clarify the best treatment approaches.
- Tension headaches are influenced by various factors, with correlations found between issues in the jaw and neck muscles and the development of headaches, but the exact cause remains unclear.
- Further research is needed to fully understand the mechanisms behind tension headaches, particularly how initial triggers lead to headache attacks, potentially involving vascular and musculoskeletal factors.
Article Synopsis
- - Situs inversus is a rare condition where major organs are mirrored from their usual positions, often found incidentally during medical procedures or imaging.
- - A case study discusses a 68-year-old male patient with pneumonia who was found to have situs inversus totalis while in the ICU for respiratory failure.
- - The disorder presents unique challenges in critical care, such as confusion during imaging, procedures, and patient monitoring, highlighting the importance of recognizing this condition for effective treatment.
Article Synopsis
- * This study examined GCs in human lymph nodes responding to unknown antigens, rather than in traditional mouse models with specific antigens.
- * The researchers found diverse B-cell clones in individual GCs but also identified shared clones, suggesting that these GCs can evolve similarly even when responding to different antigens.
Article Synopsis
- - The systematic review aims to explore how occupational therapy supports children with additional needs or disabilities in school settings by analyzing existing literature.
- - A thorough search across multiple databases identified 1954 studies, but only 18 met the criteria, showing varied occupational therapy interventions in educational environments.
- - Key findings indicate the effectiveness of occupational therapists in schools, the importance of teamwork among professionals, and the necessity of motivating students with special needs for better inclusion; however, more consistent and larger studies are needed to strengthen these results.
Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich domain (RS-domain). Such mutations can cause defective splicing and cytoplasmic mislocalization, which leads to the formation of detrimental cytoplasmic granules. Successful development of personalized therapies requires identifying the direct mechanisms of pathogenic RBM20 variants.
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