Publications by authors named "Rodrigo de Oliveira Cavagna"
Article Synopsis
- LCINS accounts for 20% of lung cancer cases, with the study focusing on the molecular profile of driver genes in Brazilian patients who never smoked.
- The investigation involved studying mutational and gene fusion status in 119 lung adenocarcinomas using advanced sequencing techniques, alongside genetic ancestry analysis.
- Results showed high mutation rates in genes like EGFR and TP53, with significant findings on ancestry influencing mutation patterns, and highlighted that a large percentage of patients have potential targets for effective treatment.
Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, known for its heterogeneity and treatment-associated toxicity, and there is a critical need for new therapeutic targets. We analyzed the somatic mutation profile of 15 driver genes in 69 Latin-Iberian molecularly characterized medulloblastomas using the Illumina TruSight Tumor 15 panel. We classified the variants based on their clinical impact and oncogenicity.
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- * A study in Brazil found that out of 147 NSCLC patients, 8.2% tested positive for NTRK fusions via immunohistochemistry, with two cases confirmed using RNA-based methods.
- * The study revealed that NTRK fusions are relatively rare in this population and highlighted the effectiveness of RNA-based nCounter for identifying NTRK fusions in small biopsy samples, with a low concordance rate between different testing methods.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) have transformed treatment for non-small-cell lung cancer (NSCLC), but better methods for selecting patients who will benefit from these therapies are necessary, particularly through gene expression profiling (GEP).
- In a study involving 135 Brazilian NSCLC patients treated with ICIs, researchers analyzed GEP from tumor tissues and found that certain signatures, such as tumor inflammation signature (TIS) and IFN-γ, were linked to better outcomes.
- Patients with high TIS levels had significantly longer overall survival after immunotherapy (29.2 months) compared to those with low levels (15.5 months), indicating that TIS and IFN-γ could serve as valuable biomarkers to guide treatment choices
Introduction: TP53 is the most frequently mutated gene in lung tumors, but its prognostic role in admixed populations, such as Brazilians, remains unclear. In this study, we aimed to evaluate the frequency and clinicopathological impact of TP53 mutations in non-small cell lung cancer (NSCLC) patients in Brazil.
Methods: We analyzed 446 NSCLC patients from Barretos Cancer Hospital.
ERBB2 exon 20 insertions may impact the clinical management of lung cancer patients. However, the frequency of ERBB2 exon 20 insertions in lung cancer patients in Brazil is scarce. Here, we analyzed 722 Brazilian non-small cell lung cancer (NSCLC) patients from Barretos Cancer Hospital that were indicated to require routine lung cancer molecular testing.
View Article and Find Full Text PDFBackground: Targeted and immunotherapies are currently moving toward early-stage settings for patients with non-small cell lung cancer (NSCLC). Predictive biomarkers data are scarce in this scenario. We aimed to describe the frequency of EGFR mutations and PD-L1 expression levels in early-stage non-squamous patients with NSCLC from a large, single Brazilian oncology center.
View Article and Find Full Text PDFBackground: Microsatellite instability (MSI) in non-small cell lung cancer (NSCLC) is uncommon; however, most studies refer to European and Asian populations. There are currently no data on MSI frequency in highly admixed populations, such as the one represented by Brazilian NSCLC patients.
Aim: This study aimed to evaluate the frequency of MSI in Brazilian NSCLC patients.
Driver mutations in non-small cell lung cancer (NSCLC) have a relevant significance for clinical management. EGFR mutations are the most important predictive biomarkers for NSCLC, although KRAS and BRAF mutations can also be prognostic and predictive biomarkers, respectively. PCR-based approaches followed by sequencing are useful for EGFR, KRAS, and BRAF mutational analysis.
View Article and Find Full Text PDFBackground: Gene fusions have been successfully employed as therapeutic targets for lung adenocarcinoma. However, tissue availability for molecular testing of multiples alterations is frequently unfeasible. We aimed to detect the presence of and rearrangements by a RNA-based single assay in Brazilian lung adenocarcinomas and to associate with clinicopathological features and genetic ancestry.
View Article and Find Full Text PDFMedulloblastoma is the most frequent malignant brain tumor in children, representing 20% of all childhood brain tumors. Currently, medulloblastomas are molecularly classified in 4 subgroups that are associated with distinctive clinicopathological features. KBTBD4 mutations were recently described in a subset of MBGRP3 and MBGRP4 medulloblastomas subgroups.
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