Publications by authors named "Rodrigo da Costa Silva"
Insights into nucleoside hydrolase from Leishmania donovani inhibition: A new bioaffinity chromatography-based screening assay and docking studies.
Camila Anchau Wegermann Evelyn Santana Bezerra Isabella Gomes de Macedo Sant'Anna Pamella Christina Ortega De Oliveira Rodrigo da Costa Silva
Bioorg Chem
May 2024
Article Synopsis
- Leishmaniasis is a serious health issue, particularly visceral leishmaniasis, and targeting nucleoside hydrolase (NH) could lead to new treatments.
- Researchers developed immobilized enzyme reactors (IMERs) using LdNH to monitor enzyme activity in real-time during liquid chromatography, successfully separating the substrate and product.
- The study identified new inhibitors, with one compound showing promising effectiveness and provided insights for designing better inhibitors through molecular modeling techniques.