Publications by authors named "Rodrigo R Krug"
Introduction: Multicenter research initiatives in Brazilian dialysis centers are scarce. We described the recruitment and implementation phases of the SARC-HD study, aimed at investigating sarcopenia and its impact on adverse clinical outcomes.
Methods: The SARC-HD is a cohort study being conducted with patients on hemodialysis in Brazil.
Article Synopsis
- Low muscle strength and function are linked to negative health outcomes in hemodialysis patients, yet reference values for muscle and physical performance tests are scarce.
- A large-scale analysis was conducted using baseline data from the SARC-HD study, focusing on handgrip strength, sit-to-stand tests, and gait speed, with results segmented by sex and age.
- Findings indicated that muscle strength and physical performance declined with age, with notable differences between males and females, and highlighted specific reference values that could serve as clinical markers for identifying patients at risk.
Article Synopsis
- The study highlights challenges in diagnosing sarcopenia among hemodialysis patients due to differing definitions from the EWGSOP2 and SDOC consensuses.
- Similar prevalence rates for sarcopenia were found using both definitions, but there was a weak overall agreement in diagnoses between the two methods.
- The results suggest that while there is some alignment in identifying severe sarcopenia cases, the discrepancies in diagnosing low muscle strength indicate a need for standardized approaches in clinical settings.
Background: Sarcopenia has been associated with adverse outcomes in patients with chronic kidney disease (CKD), particularly in those undergoing hemodialysis (HD). However, the trajectories across sarcopenia stages, their determinants, and associations with adverse clinical outcomes have yet to be comprehensively examined.
Methods: The SARC-HD is a multicenter, observational prospective cohort study designed to comprehensively investigate sarcopenia in patients on HD.