Publications by authors named "Rodrigo M Carvalho"
Dimethyl fumarate (DMF, Tecfidera) is an oral drug utilized to treat relapsing-remitting multiple sclerosis (MS). DMF treatment reduces disease activity in MS. Gastrointestinal discomfort is a common adverse effect of the treatment with DMF.
View Article and Find Full Text PDFConcrete mixing can lead to mechanical degradation of aggregates, particularly when dealing with recycled concrete aggregates. In this work, the attrition of such materials during mixing is studied by means of experiments and simulations. The effect of the presence of fines, water addition, flow configuration of the mixer (co- or counter-current) and impeller frequency is discussed.
View Article and Find Full Text PDFEthnopharmacological Relevance: Aloe vera is a widely used medicinal plant for its various biological activities. This study evaluate possible mutagenic and healing effects of the aqueous extract of A. vera (AEAV) in mice and its oxidant/antioxidant potential in different proficient and deficient Saccharomyces cerevisiae strains.
View Article and Find Full Text PDFPersistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments.
Oxid Med Cell Longev
October 2018
Article Synopsis
- - This study assessed DNA damage in breast cancer patients before and after treatment using the Comet assay and the micronucleus test in different cell types.
- - 100 women with breast cancer were compared to a control group of 50 women without cancer, revealing a significant increase in DNA damage and micronuclei in cancer patients throughout their treatment.
- - Findings indicate that breast cancer patients experience ongoing DNA lesions due to the cancer itself and treatment side effects, which tend to worsen after radiotherapy.
Occupational and life-style factors-acquired mutagenicity in agric-workers of northeastern Brazil.
Environ Sci Pollut Res Int
June 2017
Pesticides are a complex mixture of chemicals used to protect crops from a number of pests and diseases. They have been considered as potential mutagenic agents. This study aims at evaluation of the mutagenic effect of pesticide exposure to agricultural workers through chromosomal aberrations (CA) and micronucleus (MN) assay in peripheral blood lymphocytes and oral mucosal cells, respectively.
View Article and Find Full Text PDFBackground: Several studies have been published on the effect of bone-marrow stem cells on the left ventricle when acting on post- acute myocardial infarction remodeling. However, the results have been controversial.
Objective: To carry out an echocardiographic analysis of the systolic function of patients with acute myocardial infarction after autologous mononuclear bone marrow cell transplantation (AMBMCT) as performed via the intracoronary and intravenous routes.