Publications by authors named "Rodrigo Jose Videres Cordeiro de Brito"
Background: Human immunodeficiency virus (HIV) infection is a health problem in Brazil and worldwide. Without treatment, the infection can progress to Acquired Immunodeficiency Syndrome (AIDS), with a high mortality potential. The objective of this study was to analyze the time trend of AIDS mortality in Brazil, macro-regions, federal units and their respective capitals, from 2012 to 2022.
View Article and Find Full Text PDFThe IL-22 pathway has been shown to play an important role in the pathogenesis of liver fibrosis. However, little is known about the role of single-nucleotide polymorphisms (SNPs) in IL-22-related genes in relation to the severity of liver fibrosis. This study aimed to investigate the association of polymorphisms in and genes with the severity of liver fibrosis in patients with chronic hepatitis C.
View Article and Find Full Text PDFBackground: The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030. In Brazil, efforts have been undertaken to achieve this goal; there are, however, great challenges. It is important to understand the disease profile in different regions of the country in order to design strategies to fight the disease nationwide.
View Article and Find Full Text PDFAims: Liver fibrosis is the result of an exacerbated wound-healing response associated with chronic liver injury. Interleukin-22 (IL-22) plays a key role in liver disease, through either a protective or an adverse role, depending on the context. The relationship between IL-22 and its receptors IL-22R1 and IL-22BP (soluble inhibitor) in liver fibrosis is unknown.
View Article and Find Full Text PDFArticle Synopsis
- Fever of undetermined origin (FUO) is characterized by a sustained fever of 37.8 °C or higher lasting more than three weeks, without a clear diagnosis after extensive investigation.
- The main causes of FUO include infections, cancers, and non-infectious inflammatory diseases, requiring thorough medical history and exams to guide further testing.
- Initial tests should be general rather than targeted, and starting treatment before a diagnosis is typically discouraged, as it can complicate identifying the underlying issue; the mortality rate ranges from 12-35%, influenced by the cause.
Fever of undetermined origin (FUO) is a challenging entity with a striking presence in hospitals around the world and can be associated with a myriad of differential diagnoses. It is defined as axillary temperature ≥ 37.8 ° C on several occasions, lasting ≥ three weeks, in the absence of diagnosis after three days of hospital investigation or three outpatient visits.
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