Publications by authors named "Rodrigo Ivo Marques Santos"
Article Synopsis
- One of the patients represents the first documented OROV case outside the Amazon.
- Researchers discovered OROV in peripheral blood leukocytes, a finding that could improve understanding of the virus's impact and aid in rapid diagnosis of this overlooked infection.
Article Synopsis
- - Oropouche virus (OROV), a single-stranded RNA arbovirus, has led to over 500,000 cases of febrile illness in the Amazon region of Brazil, and factors like global warming and deforestation may increase its emergence in other areas.
- - Research shows that OROV causes apoptosis in HeLa cells, with DNA fragmentation and mitochondrial changes occurring about 36 hours post-infection, highlighting the role of viral replication and protein synthesis in the process.
- - Treatments with specific inhibitors indicate that while OROV can induce cell death via a mitochondrial pathway, this apoptosis can be blocked without impacting the production of new viruses, suggesting potential areas for therapeutic intervention.
