Ascidian (chordate-tunicate) and mammalian heparin enemas attenuate experimental diversion colitis.

Aim: We sought to investigate whether mammalian or ascidian Styela plicata heparin enemas could diminish inflammation in experimental diversion colitis.

Methods: Wistar-specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing mammalian or Styela plicata heparin, or saline. Enemas were administered 3 times a week in the excluded colon segment from 4 to 8 weeks after operation.

Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis.

Aim: To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.

Methods: Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine, butyrate, or saline. Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.