Publications by authors named "Rodrigo Alvarenga Rezende"
Microneedle (MN) devices comprise of micron-sized structures that circumvent biological barriers in a minimally invasive manner. MN research continues to grow and evolve; the technology was recently identified as one of the top ten overall emerging technologies of 2020. There is a growing interest in using such devices in cosmetology and dermatological conditions where the MNs mechanically disrupt the outer skin barrier layer, creating transient pathways that allow the passage of materials to underlying skin layers.
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- - Three-dimensional (3D) cell culture, particularly spheroids, effectively mimics tissue architecture and microenvironments, making them valuable for studying both healthy tissues and solid tumors.
- - The review compares dynamic and static culture methods for creating uniform 3D spheroids, discussing factors like mass transfer and shear stress, as well as highlighting the importance of computational modeling in these systems.
- - It also addresses challenges in spheroid analysis—such as measuring cell viability and gene expression—and explores various applications, including drug screening, tissue engineering, and advanced technologies like 3D bioprinting.
Introduction: Tissue engineering is a field which is currently under a great deal of investigation for the development and/or restoration of tissue and organs, through the combination of cell therapy with biomaterials. Rapid prototyping or additive manufacturing is a versatile technology which makes possible the fabrication of three dimensional (3D) structures from a wide range of materials with complex geometry and accuracy, such as scaffolds.
Aim: The aim of this study has been to investigate the interaction between mesenchymal stem cells with poly (ε-caprolactone) (PCL) biomaterials used for obtaining scaffolds through additive manufacturing.