Publications by authors named "Rodolfo Sanches Ferreira"
Article Synopsis
- CNS cancers like Glioblastoma and pediatric tumors face significant treatment challenges due to their poor response to conventional therapies such as radiation and chemotherapy.* -
- Recent research highlights the potential of the Zika virus (ZIKV) as an oncolytic treatment, showing its ability to infect and kill malignant CNS tumor cells while having a preference for tumor rather than normal cells.* -
- Experiments using hybrid co-culture models demonstrated that ZIKV replication was enhanced in tumor cells compared to normal cells, leading to notable reductions in the number of certain tumor types, although not uniformly effective across all cancers.*
Human Papillomavirus (HPV) is the most frequent etiological agent sexually transmitted. In the context of the immune response, NF-kB pathway plays an important role controlling the expression of several genes essential to cellular activity and structural and/or functional changes in components of this pathway can promote the development of several tumors. Thus, the study purpose was to evaluate the influence of NFKB1 rs28362491 and NFKBIA rs696 genetic variants on HPV infection and cervical lesions development.
View Article and Find Full Text PDFThe Zika virus (ZIKV) has shown a promising oncolytic effect against embryonal CNS tumors. However, studies on the effect of different administration routes and the ideal viral load in preclinical models are highly relevant aiming for treatment safety and efficiency. Here, we investigated the effect and effectiveness of different routes of administration, and the number of ZIKV injections on tumor tropism, destruction, and side effects.
View Article and Find Full Text PDFPurpose: FOXP3 is a marker of the T regulatory (Treg) cell subset and drives its function and homeostasis. Its expression maintains the host immunosuppressive state that favors persistence of human papillomavirus (HPV) infection and squamous intraepithelial lesion (SIL) appearance. The present study evaluated the effects of the rs3761548 and rs2232365 intronic single-nucleotide variants (SNVs) and their haplotypes on HPV infection and SIL diagnosis in HPV-infected and -uninfected women.
View Article and Find Full Text PDFGenetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study.
J Biomed Sci
September 2018
Background: Human papillomavirus (HPV) is the most common sexually transmitted virus in women worldwide. The persistence of the virus may cause warts that are considered benign lesions and low or high grade intraepithelial lesions (LSIL/HSIL). Immunological system plays an important role in the resolution of infections.
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