Distinct anal microbiome is correlated with anal cancer precursors in MSM with HIV.

Objectives: Anal cancer risk is elevated in MSM with HIV (MSMWH). Anal high-risk human papillomavirus (hr-HPV) infection is necessary but insufficient to develop high-grade squamous intraepithelial lesion (HSIL), the anal cancer precursor, suggesting additional factors. We sought to determine whether the microbiome of the anal canal is distinct by comparing it with the microbiome of stool.

Common mental disorders in Peruvian immigrant in Chile: a comparison with the host population.

Background: The Inner Santiago Health Study (ISHS) aimed to (i) estimate the prevalence of common mental disorders (CMD; i.e. depressive and anxiety disorders) among immigrants of Peruvian origin in Chile; (ii) determine whether such immigrants are at higher risk of CMD when compared with the native-born geographically matched population (i.

Gut microbiome composition and risk factors in a large cross-sectional IBS cohort.

Objective: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that is difficult to diagnose and treat due to its inherent heterogeneity and unclear aetiology. Although there is evidence suggesting the importance of the microbiome in IBS, this association remains poorly defined. In the current study, we aimed to characterise a large cross-sectional cohort of patients with self-reported IBS in terms of microbiome composition, demographics, and risk factors.

[Population estimates on HIV in Chile 2017. SPECTRUM, UNAIDS].

The Joint United Nations Program on HIV/AIDS (UNAIDS) promotes the development of population estimates related to this epidemic, based on the use of the SPECTRUM software. In Chile, the estimates are updated annually, the last one corresponding to the year 2017, a process that included the participation of representatives of the Ministry of Health with the advice of experts from the UNAIDS headquarters in Geneva. The development of the 2017 estimation process yielded a number of 67,000 people living with HIV in 2017 (lower limit of 58,000 - upper limit of 76,000), with a prevalence in the group of 15 to 49 years of 0.

[Transient left ventricular apical ballooning with dynamic outflow tract obstruction complicated by persistent hypotension].

The pathogenesis of tako-tsubo syndrome remains, nowadays, unclear: it is likely that the relevance of the different proposed mechanisms differs among specific clinical contexts. In this paper, we describe the case of a 61-year-old woman admitted to the intensive cardiac care unit for pre-syncope and persistent hypotension. Clinical and echocardiographic data were suggestive of tako-tsubo syndrome with severe dynamic left ventricular outflow tract (LVOT) obstruction and severe mitral regurgitation.

Invasive strategy following fibrinolysis in ST-elevation acute myocardial infarction.

Background: A recognized drawback of ST-elevation acute myocardial infarction (STEMI) after fibrinolysis is persistent coronary occlusion or a less than TIMI 3 flow. The present study describes the results of systematic pre-discharge coronary angiography and revascularization, whenever indicated, following fibrinolytic therapy for STEMI.

Methods: Consecutive patients admitted with the diagnosis of STEMI between April 1, 2000 and April 30, 2002 were included in the study.