Cornulacin: a new isoflavone from and its isolation, structure elucidation and cytotoxicity through EGFR-mediated apoptosis.

Chemical investigation of the methanolic extract of (Amaranthaceae), an annual wild herb collected from North Sinai, Egypt, yielded a new isoflavone cornulacin 1 and five known compounds: -feruloyltyramine 2, -feruloyl-3'-methoxytyramine 3, -caffeoyl tyramine 4, Cannabisin F 5 and (2a, 3a) lyciumamide D 6. Using MTT assay, the isolated compounds were evaluated for their cytotoxicity against pancreatic (Panc1) and ovarian (A2780) cancer cell lines. Compounds 1, 2, 3, and 4 exhibited promising cytotoxic activity against the tested cells, among which compound 1 (IC of 2.