Reproductive period and cognitive function in a representative sample of naturally postmenopausal women aged 60-64 years.

Background: Greater lifetime estrogen exposure has been postulated to result in better cognition in later life, particularly in the area of verbal memory. In women, the highest levels of endogenous estrogen occur during their reproductive period, between menarche and menopause.

Objective: To investigate the association between reproductive period and cognition.

Is this a case of simple soft tissue mass?

A 15-year-old girl reports a 1-year history of a mass on the lower portion of her left leg associated with occasional pain. Antero-posterior and lateral radiography, T1 and T2 magnetic resonance imaging (MRI), and bone/joint whole body scan were performed.

A transition-metal-catalyzed enediyne cycloaromatization.

The pentamethylcyclopentadienyl iron cation, generated from [(eta5-C5Me5)Fe(NCMe)3]PF6, triggers the room temperature cycloaromatization of acyclic and alicyclic enediynes, in the presence of either 1,4-cyclohexadiene or terpinene as the hydrogen-atom donor, to give metal-arene products in good to excellent yields. Photolysis of the metal-arene complexes liberates the arene from the metal in excellent yield. The first demonstration of a transition-metal-catalyzed cycloaromatization of conjugated enediynes has been achieved under photochemical conditions utilizing either [(eta5-C5Me5)Fe(NCMe)3]PF6 or [(eta5-C5Me5)Fe(eta6-1,2-(Prn)2C6H4)]PF6 as the catalyst precursor.

Eating Disorder Examination Questionnaire (EDE-Q): norms for young adult women.

In order to establish norms for the Eating Disorder Examination Questionnaire (EDE-Q) among young adult women, the questionnaire was administered to a large general population sample of women aged 18-42 yr in the Australian Capital Territory (ACT) region of Australia. Normative data were derived for EDE-Q subscales and for the occurrence of specific eating disorder behaviours, for each of five age bands (18-22, 23-27, 28-32, 33-37, 38-42 yr). Mean scores (SDs) for the Restraint, Eating Concern, Weight Concern and Shape Concern subscales for the total sample (n = 5,255) were, respectively, 1.

An update on the definition of "excessive exercise" in eating disorders research.

Objective: The current study informed the definition of "excessive exercise" by examining relations between exercise behavior, eating-disordered behavior, and quality of life (QOL) in a community sample of women.

Method: Self-report measures of frequency of exercise, obligatory exercise and motivation for exercise, and of eating disorder psychopathology and QOL, were completed by 3,472 women aged 18-42 years who engaged in regular exercise.

Results: The extent to which exercise is intended to influence weight or shape and the degree to which guilt is experienced when exercise is postponed were the exercise variables most strongly associated with elevated levels of eating disorder psychopathology and reduced QOL.

Hormone replacement therapy and cognition in an Australian representative sample aged 60-64 years.

Objective: To investigate the relationship between hormone replacement therapy (HRT) and level of cognitive performance intra-individual variability, and interactions with statin use, progesterone therapy and type of menopause.

Methods: A representative sample of 60-64 year olds was recruited from the Canberra and Queanbeyan regions in Australia. They were administered tests of verbal memory, working memory, speed of information processing, simple and complex reaction time, verbal intelligence and the Mini-Mental State Exam.

Phylogenetic analysis of the myostatin gene sub-family and the differential expression of a novel member in zebrafish.

The myostatin (MSTN)-null phenotype in mammals is characterized by extreme gains in skeletal muscle mass or "double muscling" as the cytokine negatively regulates skeletal muscle growth. Recent attempts, however, to reproduce a comparable phenotype in zebrafish have failed. Several aspects of MSTN biology in the fishes differ significantly from those in mammals and at least two distinct paralogs have been identified in some species, which possibly suggests functional divergence between the different vertebrate classes or between fish paralogs.

Retirement and mental health: analysis of the Australian national survey of mental health and well-being.

Nation-wide research on mental health problems amongst men and women during the transition from employment to retirement is limited. This study sought to explore the relationship between retirement and mental health across older adulthood, whilst considering age and known risk factors for mental disorders. Data were from the 1997 National Survey of Mental Health and Well-being, a cross-sectional survey of 10,641 Australian adults.

Insulin-like growth factor-I downregulates embryonic myosin heavy chain (eMyHC) in myoblast nuclei.

The obscure ability of the insulin-like growth factors (IGF-I & -II) to stimulate both myoblast proliferation and differentiation suggests that the latter effect may be mediated locally, possibly by IGF binding proteins (IGFBPs). In some cells, the growth inhibitory actions of IGFBP-5 require plasma membrane translocation and nuclear localization. Immunoreactivity of presumably endogenous IGFBP-5 was identified within proliferating rat L6 myoblast nuclei using fluorescent and confocal microscopy in separate experiments and was reduced by 100 ng/ml IGF-I in a time-dependent manner.

Age group differences in psychological distress: the role of psychosocial risk factors that vary with age.

Background: There is continuing controversy about how age affects depression and anxiety, with a lack of consistent results across studies. Two reasons for this inconsistency are age bias in measures and different patterns of exposure to risk factors across age groups in various studies.

Method: Data on anxiety and depression symptoms were collected in a community survey of 7485 persons aged 20-24, 40-44 or 60-64 years.

Lower cognitive test scores observed in alcohol abstainers are associated with demographic, personality, and biological factors: the PATH Through Life Project.

Aims: To identify variables that explain the association between alcohol abstention and cognitive performance. We hypothesized that demographic and personality variables would be important for explaining the association in all age cohorts, but that health variables would be more important in the older age-cohorts.

Design: Three age cohorts (20-24, 40-44, 60-64 years) were sampled randomly, yielding a total of 7485 participants, with data from 602 alcohol abstainers and 4158 light or moderate drinkers used in this study.

Non-linear relationships between cognitive function and alcohol consumption in young, middle-aged and older adults: the PATH Through Life Project.

Aims: To investigate associations, including non-linear relationships, between cognitive function and alcohol consumption, testing for moderating effects of age and gender and for differences across outcome measures. Design Cross-sectional general population samples of three age cohorts. Setting Canberra and Queanbeyan, Australia.

Tissue-specific expression of Fgfr2b and Fgfr2c isoforms, Fgf10 and Fgf9 in the developing chick mandible.

Experimental evidence has demonstrated the importance of FGF signalling in morphogenesis of the mandibular processes. FGFs transmit their signals through four tyrosine kinase transmembrane receptors (FGFRs). Alternative splicing in FGFRs including FGFR2 generates different isoforms that exhibit different ligand-specificities, exclusive tissue distributions and specific biological functions.

The health effects of jobs: status, working conditions, or both?

Background: This study investigates whether the association of job strain and insecurity with health differs by status.

Methods: A cross-sectional study of 2,249 employed workers aged 40-44 years conducted in two regions in south-east Australia in 2000 used a self-completed questionnaire to collect data. Multivariate analyses were used to compare depression, anxiety, physical health and general practitioner (GP) visits over 12 months across categories of job strain and insecurity for three status groups (high, middle and low).

An eta(6)-dienyne transition-metal complex.

The ruthenium complexes, [(eta5-C5R5)Ru(CH3CN)3]PF6 (1-Cp*, R = Me; 1-Cp, R = H), underwent reaction with both 1-(2-chloro-1-methylvinyl)-2-pentynyl-(Z)-cyclopentene (6-Z) and 1-(2-chloro-1-methylvinyl)-2-pentynyl-(E)-cyclopentene (6-E) to give (eta5-C5R5)Ru[eta6-(5-chloro-4-methyl-6-propylindan)]PF6 (7-Cp*, R = Me; 7-Cp, R = H). In a similar fashion, reaction of 1-Cp and 1-Cp* with 1-isopropenyl-2-pent-1-ynylcyclopentene (8) led to the formation of (eta5-C5R5)Ru(eta6-4-methyl-6-propylindan)]PF6 (9-Cp*, R = Me; 9-Cp, R = H). The reaction of 1-Cp* with 8 at -60 degrees C in CDCl3 solution led to observation of the eta6-dienyne complex, (eta5-C5Me5)Ru[eta6-(1-isopropenyl-2-pent-1-ynylcyclopentene)]PF6 (10), by 1H NMR spectroscopy.

Assessing quality of life in eating disorder patients.

Objective: To examine quality of life among subgroups of eating disorder patients.

Method: Self-report questionnaires which included two quality of life measures were completed by 87 individuals referred for treatment to the Australian Capital Territory Eating Disorders Day Program. Health-related quality of life, as measured by the Medical Outcomes Study 12-item Short Form Mental Component Summary scale, and subjective quality of life, as measured by subscales of the World Health Organization Brief Quality of Life Assessment Scale (WHOQOL-BREF), were compared among individuals who received the diagnosis of anorexia nervosa purging subtype (n = 15), anorexia nervosa restricting subtype (n = 19), bulimia nervosa (n = 40) and binge eating disorder (n = 10), and among a general population sample of young adult women employed as a control group (n = 495).

Disability associated with community cases of commonly occurring eating disorders.

Objective: To examine disability associated with community cases of the more commonly occurring eating disorders and with particular eating disorder behaviours.

Method: Self-report questionnaires, which included measures of eating disorder symptoms and impairment in everyday functioning, were completed by 495 female residents of the Australian Capital Territory region aged between 18 and 45 years. A structured interview for the assessment of eating disorders was completed by a subgroup (n = 208) of participants.

Childhood adversity in an Australian population.

Background: The impact of adversity in childhood is well established in clinical populations, but there is little information about adversity in wider populations. The aim of this paper is to report and to explore the distribution of childhood family adversity in an Australian population.

Method: A total of 7485 randomly selected subjects in 20-24, 40-44 and 60-64 year age bands were interviewed at the outset of a longitudinal community study of psychological health in the Canberra region of Australia.

Pet ownership and health in older adults: findings from a survey of 2,551 community-based Australians aged 60-64.

Background: It is commonly assumed that owning a pet provides older residents in the community with health benefits including improved physical health and psychological well-being. It has also been reported that pet owners are lower on neuroticism and higher on extraversion compared with those without pets. However, findings of research on this topic have been mixed with a number of researchers reporting that, for older people, there is little or no health benefit associated with pet ownership.

Mode of delivery, but not questionnaire length, affected response in an epidemiological study of eating-disordered behavior.

Background And Objectives: The effects of questionnaire length and mode of delivery on response rates were examined in an epidemiological study of eating-disordered behavior.

Methods: Short (8 pages) and long (14 pages) questionnaires were posted or hand-delivered to a community sample of 802 women. Nonrespondents who received the first questionnaire by hand delivery received a reminder letter and replacement questionnaire by post; those who received the initial questionnaire by post were further randomized to receive the first reminder by hand delivery or by post, in short or long form.

Job strain, job insecurity, and health: rethinking the relationship.

Job strain (high demands and low control) is a widely used measure of work stress. The authors introduce a new way of looking at work stress by combining job strain with job insecurity, a combination increasingly prevalent in contemporary economies, using data from a cross-sectional survey (N = 1,188) of mid-aged Australian managers and professionals. Those reporting both strain and insecurity showed markedly higher odds for mental and physical health problems (depression: odds ratio [OR] 13.