Efficacy of [Lu]Lu-DOTATATE in metastatic neuroendocrine neoplasms of different locations: data from the SEPTRALU study.

Background: Peptide receptor radionuclide therapy (PRRT) is one of the most promising therapeutic strategies in neuroendocrine neoplasms (NENs). Nevertheless, its role in certain tumor sites remains unclear. This study sought to elucidate the efficacy and safety of [Lu]Lu-DOTATATE in NENs with different locations and evaluate the effect of the tumor origin, bearing in mind other prognostic variables.

Dependency of the remnant I-NaI biokinetics on the administered activity in patients with differentiated thyroid cancer.

Purpose: To study the dependency of the effective half-life on the administered activity and the correlation between the time-integrated activity and the remnant uptake at 2d and 7d in patients treated for DTC with 1.11 GBq, 3.7 GBq or 5.

A retrospective study on the potential of Tc-HDP imaging before therapy for individualizing treatments with Ra-Cl for metastatic castration resistant prostate cancer.

Purpose: Research on dose-effect correlation is necessary to move toward an individualization of treatments of metastatic castration resistant prostate cancer (mCRPC) with Ra-Cl . We first looked for a possible correlation of Tc-HDP lesion uptake in pretreatment whole-body scans (WBSs) with lesion absorbed dose. Moreover, we looked for a possible correlation of Tc-HDP lesion uptake in pretreatment WBSs and of lesion absorbed dose with relative change in the Tc-HDP lesion uptake obtained from pre- and post-treatment WBSs in patients treated for mCRPC with six cycles of Ra-Cl .

Microdosimetry-based determination of tumour control probability curves for treatments with Ac-PSMA of metastatic castration resistant prostate cancer.

We performed Monte Carlo simulations in order to determine, by means of microdosimetry calculations, tumour control probability (TCP) curves for treatments with Ac-PSMA of metastatic castration resistant prostate cancer (mCRPC). Realistic values of cell radiosensitivity, nucleus size and lesion size were used for calculations. As the cell radiosensitivity decreased, the nucleus size decreased and the lesion size increased, the absorbed dose to reach a given TCP increased.

Feasibility and limitations of quantitative SPECT for Ra.

The aim of this paper is to investigate the feasibility and limitations of activity-concentration estimation for Ra using SPECT. Phantom measurements are performed using spheres (volumes 5.5 mL to 26.

Analysis of activity uptake, effective half-life and time-integrated activity for low- and high-risk papillary thyroid cancer patients treated with 1.11 GBq and 3.7 GBq of I-NaI respectively.

Purpose: To analyse the activity uptakes, effective half-lives and time-integrated activities, of relevance for remnant dosimetry, for patients treated for papillary thyroid cancer (PTC) with a different amount of activity of I-NaI.

Methods: Fifty patients were included. Of those, 18 patients had low-risk PTC and were treated with 1.

Outcomes after a first and/or second salvage treatment in patients with oligometastatic prostate cancer recurrence detected by (18-F) choline PET-CT.

Objective: The primary objective of this study was to assess clinical outcomes in patients with oligometastatic prostate cancer recurrence after single or repeated salvage radiation treatment.

Methods: Forty-nine consecutive prostate cancer patients diagnosed with oligometastatic recurrence on Ch-PET have been prospectively treated. Seven (23%) patients had castrate-resistant disease.

Comparison of microdosimetry-based absorbed doses to control tumours and clinically obtained tumour absorbed doses in treatments with Ra.

We performed Monte Carlo simulations in order to determine by means of microdosimetry calculations the average number of hits to the cell nucleus required to reach a tumour control probability (TCP) of 0.9, [Formula: see text], for the source geometry of a nucleus embedded in a homogeneous distribution of Ra atoms. From the results obtained and following the MIRD methodology, we determined the values of lesion absorbed doses needed to reach a TCP of 0.

Detection and quantification of Ra uptake in bone metastases of patients with castration resistant prostate carcinoma, with the aim of determining the absorbed dose in the metastases.

Purposes: To obtain the necessary acquisition and calibration parameters in order to evaluate the possibility of detecting and quantifying Ra uptake in bone metastases of patients treated for castration resistant prostate carcinoma. Furthermore, in the cases in which the activity can be quantified, to determine the absorbed dose.

Material And Methods: Acquisitions from a Petri dish filled with Ra were performed in the gamma camera.

Whole-remnant and maximum-voxel SPECT/CT dosimetry in I-NaI treatments of differentiated thyroid cancer.

Purpose: To investigate the possible differences between SPECT/CT based whole-remnant and maximum-voxel dosimetry in patients receiving radio-iodine ablation treatment of differentiated thyroid cancer (DTC).

Methods: Eighteen DTC patients were administered 1.11 GBq of I-NaI after near-total thyroidectomy and rhTSH stimulation.

Whole-remnant and maximum-voxel SPECT/CT dosimetry in I-NaI treatments of differentiated thyroid cancer.

Purpose: To investigate the possible differences between SPECT/CT based whole-remnant and maximum-voxel dosimetry in patients receiving radio-iodine ablation treatment of differentiated thyroid cancer (DTC).

Methods: Eighteen DTC patients were administered 1.11 GBq of I-NaI after near-total thyroidectomy and rhTSH stimulation.

Diaschisis and neuropsychological performance after cerebellar stroke.

The cerebellum has been implicated in higher-order behavior. Blood flow studies (SPECT) have shown that cerebral diaschisis can appear after cerebellar lesions and this phenomenon could serve as a basis for a potential neuropsychological derangement after cerebellar insults. Our objectives in this study were to delineate the neuropsychological profile after cerebellar stroke, to evaluate cerebral diaschisis as measured by SPECT and to correlate the findings.

Differential uptake of systemic fluorochrome Hoechst 33342 in lung and liver metastasis of B16 melanoma.

The growth and vascularization patterns of B16 melanoma colonies in the liver and lungs were measured and compared by histological techniques and dye diffusion patterns after injection of the fluorochrome Hoechst 33342. In the liver, the fluorescent pattern of dye diffusion revealed that uninodular tumours measuring up to 146 microns in diameter were not functionally vascularized. However, when the nodules fused to give rise to multinodular tumours measuring between 256 and 366 microns in diameter, a reticular dye diffusion pattern revealed functional tumour vascularization.

Morpho-functional study of vascular fluorochrome delivery to lung and liver metastases of Lewis lung carcinoma (3LL).

The growth of 3LL liver and lung metastases related to its vascular organization was studied by morphological and functional methods, using the Hoechst 33342 fluorescent DNA staining technique. Experimental liver and lung metastases were produced in syngeneic C57BL/6 mice by injection of 3LL tumor cells into a lateral tail vein or into the spleen, respectively. The resulting neoplasms were composed of large cells arranged in sheets with a thin irregularly distributed stroma.