Publications by authors named "Rocky Fischer"
Quantitative Imaging Assessment for Clinical Trials in Oncology.
J Natl Compr Canc Netw
December 2019
Background: Objective radiographic assessment is crucial for accurately evaluating therapeutic efficacy and patient outcomes in oncology clinical trials. Imaging assessment workflow can be complex; can vary with institution; may burden medical oncologists, who are often inadequately trained in radiology and response criteria; and can lead to high interobserver variability and investigator bias. This article reviews the development of a tumor response assessment core (TRAC) at a comprehensive cancer center with the goal of providing standardized, objective, unbiased tumor imaging assessments, and highlights the web-based platform and overall workflow.
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- Researchers conducted a comprehensive study on colorectal cancer (CRC) by sequencing the genomes of over 1,400 CRC cases and 720 controls, ultimately analyzing data from nearly 125,000 individuals.
- They found a significant protective variant at the CHD1 gene and identified 40 new genetic signals associated with CRC, highlighting the involvement of low-frequency variants and various biological pathways.
- The study indicates that CRC risk is influenced by many genes and suggests that further research, especially on rare variants, could enhance understanding of CRC and shape personalized treatment and screening efforts.
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk.
Methods: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315).