Publications by authors named "Rocio Villalobos-Manzo"
Identification of Transferrin Receptor 1 (TfR1) Overexpressed in Lung Cancer Cells, and Internalization of Magnetic Au-CoFeO Core-Shell Nanoparticles Functionalized with Its Ligand in a Cellular Model of Small Cell Lung Cancer (SCLC).
Rocío Villalobos-Manzo Emmanuel Ríos-Castro José Manuel Hernández-Hernández Goldie Oza Mauricio A Medina
Pharmaceutics
August 2022
Lung cancer is, currently, one of the main malignancies causing deaths worldwide. To date, early prognostic and diagnostic markers for small cell lung cancer (SCLC) have not been systematically and clearly identified, so most patients receive standard treatment. In the present study, we combine quantitative proteomics studies and the use of magnetic core-shell nanoparticles (mCSNP's), first to identify a marker for lung cancer, and second to functionalize the nanoparticles and their possible application for early and timely diagnosis of this and other types of cancer.
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- Autoimmune lymphoproliferative syndrome (ALPS) is a rare immune disorder caused by defects in the lymphocyte apoptotic pathway, leading to misdiagnosis challenges.
- The study focused on two children with suspected ALPS, analyzing their blood cells and sequencing relevant genes for mutations linked to the disorder.
- Key findings included a significant mutation in one patient that caused protein truncation, while proteomic analysis in the other revealed altered levels of proteins related to cell cycle regulation and immune response, potentially explaining the disease's impact.