Efficacy and safety of topical sevoflurane in the treatment of chronic skin ulcers.

Purpose: Results of efficacy and safety assessments of topical sevoflurane use in patients with long-term treatment-refractory vascular ulcers are reported.

Methods: Patients were randomly assigned to receive sevoflurane instillations (1 mL per cm of ulcer area 1-4 times daily) plus standard wound care (ulcer cleaning, debridement, and dressing changes) or standard care only. Topical sevoflurane was initiated during hospitalization, with self- or nurse-administered instillations continued after discharge.