Publications by authors named "Rocio Martin-Alvarez"
Acetylcholine (ACh) is involved in the modulation of the inflammatory response. ACh levels are regulated by its synthesizing enzyme, choline acetyltransferase (ChAT), and by its hydrolyzing enzymes, mainly acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). A more comprehensive understanding of the cholinergic system in experimental autoimmune encephalomyelitis (EAE) disease progression could pave the path for the development of therapies to ameliorate multiple sclerosis (MS).
View Article and Find Full Text PDFA neural network model has been developed to predict the inhibitory capacity of any chemical structure to be a phosphodiesterase 7 (PDE7) inhibitor, a new promising kind of drugs for the treatment of neurological disorders. The numerical definition of the structures was achieved using CODES program. Through the validation of this neural network model, a novel family of 5-imino-1,2,4-thiadiazoles (ITDZs) has been identified as inhibitors of PDE7.
View Article and Find Full Text PDFArticle Synopsis
- Phosphodiesterase (PDE) 7 plays a role in inflammation and is found in immune cells and the brain, making it a target for new neurological drugs.
- Recent studies show that PDE7 inhibitors can elevate cAMP levels in cells, helping reduce inflammation—a key strategy for neuroprotection.
- Researchers discovered a new group of PDE7 inhibitors that not only lower inflammation in brain cells but also improve symptoms in a mouse model of multiple sclerosis, suggesting their potential as innovative treatments for the disease.