Are the ESPGHAN criteria valid with the chemioluminiscence method? Analysis of potential diagnostic errors.

Objectives: To determine how many patients may have received a mistaken diagnosis of coeliac disease using the ESPGHAN 2012 and 2020 criteria without performance of biopsy when using chemiluminescence, and to evaluate possible causes of interference affecting anti-tissue transglutaminase antibody results obtained with this technique.

Methods: Retrospective and descriptive study of biopsies of patients with elevated tissue transglutaminase antibodies (tTGA) measured by chemiluminescence in a tertiary care hospital.

Results: The sample included 135 patients with a mean age of 7.