Assessment trial of the effect of enteral insulin on the preterm infant intestinal microbiota.

Background: Insulin might be associated with changes in infant gastrointestinal microbiota. The objective of this randomized controlled trial was to assess the efficacy of two doses of recombinant human(rh) enteral insulin administration compared to placebo in intestinal microbiota.

Methods: 19 preterm patients were recruited at the NICU of La Paz University Hospital (Madrid, Spain).