Impact of satisfaction and motivation on occupational stress in operating room nursing: a pilot study.

Objective: To evaluate how job satisfaction and motivation impact the perception of occupational stress among operating room nursing professionals.

Methods: This observational cross-sectional study was conducted at a major federal university hospital in Northeast Brazil, with data collection occurring in May and June of 2023.

Results: Among the 92 respondents, which included nurses (35; 38.

Melatonin for Huntington's Disease (HD) gene carriers with HD-related sleep disturbance - A pilot study.

Background: Sleep disorders are common in people with Huntington's Disease (HD). Possible causes include disruptions to the body's internal clock and changes in melatonin levels. Although melatonin is known to treat sleep disruptions related to circadian rhythm disorders, its effects on HD patients have not been thoroughly explored.

Anatomopathological characterization of hepatocellular carcinoma in a jaguar (Panthera onca).

A 21-year-old jaguar (Panthera onca) with a low body score, pale ocular mucosa, severe dehydration, and decubitus eschar was referred to our veterinary hospital. The patient died and underwent a postmortem examination to establish a diagnosis. Macroscopic evaluation revealed a reddish-black, well-defined, focally extensive mass measuring 12 cm in diameter on the visceral surface involving the left lateral lobe of the liver.

Frequency of depression in Huntington's disease: A systematic review and meta-analysis.

BackgroundHuntington's disease (HD) is a hereditary neurodegenerative disease characterized by a combination of motor, cognitive, and mental health issues, with depression being the most common. Despite its importance, the relationship between depression and disease progression is still debatable.ObjectiveThe primary objective of this study was to examine the frequency of depression across different disease stages in individuals with HD.

Cardiac Baroreflex Is Preserved After the Recovery From COVID-19 Men and Women.

We sought to investigate whether mild COVID-19 impairs cardiac baroreflex sensitivity (cBRS), using the modified Oxford protocol, in young healthy men and women 12-14 weeks after recovering from the infection. Participants were distributed into two groups: Non-COVID-19 group (NCG: men n = 6 [30 ± 3years; 26 ± 1 kg/m] and women n = 5 [25 ± 1 years; 25 ± 1 kg/m]) and recovered from COVID-19 group (RCG: men n = 6 [29 ± 3 years; 25 ± 1 kg/m] and women n = 10 [32 ± 4 years; 22 ± 1 kg/m]), the RCG tested positive (RT-PCR) 12 to 14 weeks before the protocol. Beat-to-beat finger blood pressure (BP) and heart rate (HR) were measured during a bolus of sodium nitroprusside (SNP) and phenylephrine (PHE), in a control condition and during cold pressor test (CPT) and moderate dynamic handgrip exercise (GRIP).

Biodegradable Film Is Enriched with Pomegranate Seed Oil and Microalgae for Preservation of Cajarana ().

This study aimed to develop and characterize biodegradable films made from pectin, pomegranate seed oil, and different microalgae (, sp., and ) and to evaluate their applicability as packaging by verifying their effect on the conservation and postharvest quality of cajarana (). The films proposed in this study were assessed for their physical, optical, and mechanical attributes, as well as the physicochemical characteristics of the fruits coated with the films after 14 days of storage at 10 ± 1 °C and relative humidity of 60 ± 5%.

Efficacy and safety of elinzanetant in vasomotor symptoms associated with menopause: A meta-analysis of randomized controlled trials.

Objective: To evaluate the efficacy and safety of elinzanetant compared to placebo in patients experiencing vasomotor symptoms (VMS) associated with menopause.

Methods: A systematic search of PubMed, Embase, and Cochrane databases identified randomized clinical trials (RCTs) comparing elinzanetant and placebo in patients with menopause-related VMS. Statistical analyses pooled mean difference (MD) and risk ratio (RR) with 95% confidence intervals (CI) using R Studio 4.

Cardiovascular Effects of Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis.

Background: Semaglutide has emerged as an effective medication for treating type 2 diabetes mellitus (DM). However, the cardiovascular effects and safety of this agent in patients with heart failure with preserved ejection fraction (HFpEF) are unclear.

Objective: This systematic review and meta-analysis aimed to assess the clinical and laboratory effects of semaglutide compared to placebo in patients with HFpEF.

Breathing Easy in Maricopa County, Arizona: Empowering K-12 Schools With a Novel Nurse Coaching Model to Facilitate Implementation of a County-Wide School-Based Stock Albuterol Inhaler Program.

To reduce chronic school absenteeism and morbidity and mortality among school-aged children, the prompt administration of albuterol sulfate in schools remains vital. School-based stock inhaler programs are a practical approach to ensure equitable access to life-saving rescue medication for students. School and community partnerships can potentially strengthen program implementation and fidelity by integrating evidence-based practices into routine care.

From ideation to real context of use of a digital solution to promote physical and cognitive training for older adults.

This study describes the process of designing and developing the user interface of a digital solution aiming to promote physical and cognitive training (DanceMove) and testing for its usability by community-dwelling older adults. This study is subdivided into four phases: (i) concept and ideation, (ii) design and development of the prototype, (iii) testing of the functional mock-ups, and (iv) testing of the prototype in the laboratory and in the real context of use. Through the different phases of the study technological and healthcare professionals and users were involved.

Effectiveness of Integrated Digital Solutions to Empower Older Adults in Aspects Related to Their Health: Systematic Review and Meta-Analysis.

Background: Digital solutions, such as mobile apps or telemonitoring devices, are frequently considered facilitators in the process of empowering older adults, but they can also act as a source of digital exclusion or disempowerment if they are not adequate for older adults' needs and characteristics.

Objective: This study aimed to synthesize and critically evaluate existing evidence on the effectiveness of integrated digital solutions that enable interaction for empowering older adults in aspects related to their health and to explore potential factors (eg, type of technology, participants' characteristics) impacting effectiveness.

Methods: A systematic search was carried out in PubMed, ScienceDirect, SCOPUS, EBSCO, and SciELO using a combination of terms informed by previous reviews on empowerment.

MonitoraSB: an innovation for monitoring and strengthening oral health in primary health care in Brazil.

Objective: This study describes the methodology used in the development of MonitoraSB, an innovation in the field of evaluating and monitoring oral health services in primary health care (PHC) in Brazil, and it discusses its characteristics and possible uses.

Methods: MonitoraSB includes a matrix of indicators and digital tools, developed in collaboration with oral health team dentists and oral health managers. The indicators evaluate the provision and management of oral health services and were developed on the basis of the model for evaluating the effectiveness of oral health care.

Overprescription of antibiotics in Brazilian dental clinics: an evaluation of current practices.

The use of antibiotics by dentist surgeons faces a lack of consensus among professionals and researchers, whether in relation to prophylaxis, or at least regarding the real need for their use. Recent studies increasingly question the use of prophylactic antibiotic therapy in healthy patients. This study aimed to evaluate the knowledge of dentist surgeons working in offices across Brazil regarding antibiotic use protocols and antibiotic resistance.

Zileuton, a 5-Lypoxigenase Inhibitor, is Antiparasitic and Prevents Inflammation in the Chronic Stage of Heart Chagas Disease.

Chronic Chagas cardiomyopathy is associated with an unbalanced immune response and impaired heart function, and available drugs do not prevent its development. Zileuton (Zi), a 5-lypoxigenase inhibitor, affects inflammatory/pro-resolution mediators. Herein, Zi treatment in the early phase of infection reduced parasitemia associated mainly with the direct effect of Zi on the parasite, and the enzyme epoxide hydrolase was the potential molecular target behind the trypanocidal effect.

A Novel Machine Learning-based Predictive Model of Clinically Significant Prostate Cancer and Online Risk Calculator.

Objective: To create a machine-learning predictive model combining prostate imaging-reporting and data system (PI-RADS) score, PSA density, and clinical variables to predict clinically significant prostate cancer (csPCa).

Methods: We evaluated a cohort of patients who underwent prostate biopsy for suspected prostate cancer (PCa) in New Zealand, Australia, and Switzerland. We collected data on age, body mass index (BMI), PSA level, prostate volume, PSA density (PSAD), PI-RADS scores, previous biopsy, and corresponding histology results.

Investigating the Biological Efficacy of Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF): A Study on Cytokine Dynamics and Osteoblast Behavior.

The development of effective biomaterials for tissue regeneration has led to the exploration of blood derivatives such as leucocyte- and platelet-rich fibrin (L-PRF). A novel variant, Albumin-Enriched Platelet-Rich Fibrin (Alb-PRF), has been introduced to improve structural stability and bioactivity, making it a promising candidate for bone regeneration. This study aimed to evaluate Alb-PRF's capacity for cytokine and growth factor release, along with its effects on the proliferation, differentiation, and mineralization of human osteoblasts in vitro.

Effect of Blood Sampling Time After Colostrum Intake on the Concentration of Metabolites Indicative of the Passive Immunity Transfer in Newborn Dairy Calves.

Due to the synepitheliochorial placental structure, bovines show no maternal antibody flow from mother to fetus during pregnancy, resulting in an agammaglobulemic newborn [...

Stereoselective Ring-Opening Reaction of α-Fluorinated Oxetanes: A Practical and Theoretical Investigation.

The ring-opening reaction of fluorinated oxetanes by halides, including alkylidene oxetanes and spirocyclic oxetanes, was highly stereoselective and directed by the presence of a fluorine atom. This reaction allowed a stereoselective preparation of tetrasubstituted alkenes and substituted pyrrolidines containing all-carbon quaternary centers. Theoretical calculations were performed to shed light on experimentally observed regioselectivity in the opening of oxetane derivatives.

Heart-lung crosstalk in acute respiratory distress syndrome.

Acute Respiratory Distress Syndrome (ARDS) is initiated by a primary insult that triggers a cascade of pathological events, including damage to lung epithelial and endothelial cells, extracellular matrix disruption, activation of immune cells, and the release of pro-inflammatory mediators. These events lead to increased alveolar-capillary barrier permeability, resulting in interstitial/alveolar edema, collapse, and subsequent hypoxia and hypercapnia. ARDS not only affects the lungs but also significantly impacts the cardiovascular system.

Psychometric properties of an online psychotherapy advantages and disadvantages instrument: Preliminary results of a multi-center pilot study.

Unlabelled: We verified the need for instruments that could assess the perceptions of patients, therapists, and psychotherapy supervisors about online Psychotherapy.

Objectives: to Build a scale of advantages and disadvantages of online psychotherapy.

Method: A pilot cross-sectional multicenter sample collected from 2020 to 2021 of 129 patients, 20 therapists, and 35 supervisors.

Home Participation of Infants With and Without Biological Risk in the First Year of Life: A Cross-Sectional and Comparative Study.

Aim: To compare caregiver-reported current and desired home participation of infants with and without biological risk in the first year of life.

Method: Observational, cross-sectional and comparative study. Caregivers of 48 infants with (mean corrected age = 5.

Telehealth of Infants at Risk During the COVID-19 Pandemic: Physical Therapists' and Caregiver's Perceptions and Costs.

Aim: We aimed to describe telehealth used to detect infants at risk of neurodevelopmental delay and assess the assessors' and caregivers' perceptions and costs.

Methods: This was an observational study in which five physical therapists applied the General Movement Assessment, the neurological exam based on the Hammersmith Infant Neurological Examination, and the Alberta Infant Motor Scale telehealth in 65 infants at risk of neurologic delay during the COVID-19 pandemic. The perceptions of assessors and caregivers were assessed using a questionnaire.

Health Promoting School Program From Affordable Health Initiative: Implementation Process in Brazilian Schools.

Background: This study evaluated stakeholders' perceptions regarding the initial implementation process of the health promoting school model proposed by the affordable health initiative (AHI HPS model) in schools of Belo Horizonte/BRA.

Methods: The model has been implemented since 2019, by an implementation committee (IC) with members from university, health, and education sectors. Data were collected from records of the IC meetings (n = 10) and interviews with 5 IC members to evaluate the model's acceptability, adoption, appropriateness, and feasibility.

SheepEye: a based-web app for real-time diagnosis of sheep anemia.

is an extremely harmful blood-feeding nematode affecting small ruminants, leading to anemia, weight loss, and, in severe cases, animal death. Traditional methods of monitoring anemia in sheep, such as regular physical examinations by veterinarians and laboratory tests, can be expensive and time-consuming. In this work, we propose an anemia monitoring system that uses a web-based app.