Seasonal productivity of the equatorial Atlantic shaped by distinct wind-driven processes.

The eastern equatorial Atlantic hosts a productive marine ecosystem that depends on upward supply of nitrate, the primary limiting nutrient in this region. The annual productivity peak, indicated by elevated surface chlorophyll levels, occurs in the Northern Hemisphere summer, roughly coinciding with strengthened easterly winds. For enhanced productivity in the equatorial Atlantic, nitrate-rich water must rise into the turbulent layer above the Equatorial Undercurrent.

Synthesis of 4-hydroxypiperidines containing a quaternary stereocenter by aza-Prins cyclization.

A straightforward and highly diastereoselective synthesis of -4-hydroxypiperidines is presented. This method allows access to C2 and C4 substituted piperidines, bearing a tetrasubstituted carbon stereocenter at C4. -Disubstituted homoallylic amines and ketoaldehydes as carbonyl partners have been rarely used in aza-Prins cyclizations, expanding the scope of this reaction.

Contributions of Long-Read Sequencing for the Detection of Antimicrobial Resistance.

Background: In the context of increasing antimicrobial resistance (AMR), whole-genome sequencing (WGS) of bacteria is considered a highly accurate and comprehensive surveillance method for detecting and tracking the spread of resistant pathogens. Two primary sequencing technologies exist: short-read sequencing (50-300 base pairs) and long-read sequencing (thousands of base pairs). The former, based on Illumina sequencing platforms (ISPs), provides extensive coverage and high accuracy for detecting single nucleotide polymorphisms (SNPs) and small insertions/deletions, but is limited by its read length.

Determinants of clinical response to injection laryngoplasty in unilateral vocal fold paralysis: a systematic review and meta-analysis.

Background: Unilateral vocal fold paralysis (UVFP) significantly impairs vocal function, affecting patients' quality of life. Injection laryngoplasty, a primary treatment modality for UVFP, varies in effectiveness based on the material used, injection volume, and procedural nuances. This study aims to systematically analyze how these factors influence treatment outcomes to optimize intervention strategies.

Complementary and alternative medicine in HIV care: frequency of consumption, risks and interactions with antiretroviral therapy.

Objectives: People living with HIV (PLWH) are common users of complementary and alternative medicine (CAM). The main objective of this study was to study the frequency and patterns of CAM natural products use in a large cohort of PLWH and to identify potential drug-drug interactions (DDIs) and the impact on their antiretroviral treatment (ART) adherence and efficacy.

Methods: This was a cross-sectional multicenter survey including 420 PLWH from different Spanish hospitals.

Functional imaging guided stereotactic ablative body radiotherapy (SABR) with focal dose escalation and bladder trigone sparing for intermediate and high-risk prostate cancer: study protocol for phase II safo trial.

Background: Stereotactic ablative body radiotherapy (SABR) is an emerging treatment alternative for patients with localized low and intermediate risk prostate cancer patients. As already explored by some authors in the context of conventional moderate hypofractionated radiotherapy, focal boost of the index lesion defined by magnetic resonance imaging (MRI) is associated with an improved biochemical outcome. The objective of this phase II trial is to determine the effectiveness (in terms of biochemical, morphological and functional control), the safety and impact on quality of life, of prostate SABR with MRI guided focal dose intensification in males with intermediate and high-risk localized prostate cancer.

Synthesis and Chemoinformatic Analysis of Fluorinated Piperidines as 3D Fragments for Fragment-Based Drug Discovery.

The concise synthesis of a small library of fluorinated piperidines from readily available dihydropyridinone derivatives has been described. The effect of the fluorination on different positions has then been evaluated by chemoinformatic tools. In particular, the compounds' p's have been calculated, revealing that the fluorine atoms notably lowered their basicity, which is correlated to the affinity for hERG channels resulting in cardiac toxicity.

Using deep learning to track time × frequency whistle contours of toothed whales without human-annotated training data.

Many odontocetes produce whistles that feature characteristic contour shapes in spectrogram representations of their calls. Automatically extracting the time × frequency tracks of whistle contours has numerous subsequent applications, including species classification, identification, and density estimation. Deep-learning-based methods, which train models using analyst-annotated whistles, offer a promising way to reliably extract whistle contours.

Immediate Effect of Dry Needling on the Viscoelastic Properties of a Trigger Point on the Infraspinatus Muscle Measured with MyotonPRO.

This article investigates the immediate effects of a dry needling (DN) puncture on the viscoelastic properties (tone, stiffness, elasticity) of a trigger point (TP) in the infraspinatus muscle in non-traumatic chronic shoulder pain. Forty-eight individuals with non-traumatic chronic shoulder pain were recruited. The presence of a TP in the infraspinatus muscle was confirmed by a standardized palpatory exam.

Accessing spiropiperidines from dihydropyridones through tandem triflation-allylation and ring-closing metathesis (RCM).

A novel approach to build 2-spiropiperidine moieties starting from dihydropyridones was developed. The triflic anhydride-promoted conjugate addition of allyltributylstannane onto dihydropyridones allowed for the formation of bis-alkenyl intermediates that were converted to the corresponding spirocarbocycles with excellent yields ring closing metathesis. The vinyl triflate group generated on these 2-spiro-dihydropyridine intermediates could be successfully used as a chemical expansion vector for further transformations namely Pd-catalyzed cross-coupling reactions.

Ecological inferences about marine mammals from passive acoustic data.

Monitoring on the basis of sound recordings, or passive acoustic monitoring, can complement or serve as an alternative to real-time visual or aural monitoring of marine mammals and other animals by human observers. Passive acoustic data can support the estimation of common, individual-level ecological metrics, such as presence, detection-weighted occupancy, abundance and density, population viability and structure, and behaviour. Passive acoustic data also can support estimation of some community-level metrics, such as species richness and composition.

Diagnostic and Therapeutic Management of Infection in Primary Care: Perspective of Application in France and Narrative Review of the Literature.

Background: () infection affects 30% to 40% of people in industrialized countries.

Aim: This study aimed to synthesize knowledge on the diagnostic and therapeutic management of infection in general practice in people under 40 years of age.

Method: A narrative review of the literature with an inductive content analysis of the articles was performed.

Silbido profundo: An open source package for the use of deep learning to detect odontocete whistles.

This work presents an open-source matlab software package for exploiting recent advances in extracting tonal signals from large acoustic data sets. A whistle extraction algorithm published by Li, Liu, Palmer, Fleishman, Gillespie, Nosal, Shiu, Klinck, Cholewiak, Helble, and Roch [(2020). Proceedings of the International Joint Conference on Neural Networks, July 19-24, Glasgow, Scotland, p.

Antibiotic heteroresistance in ESKAPE pathogens, from bench to bedside.

Background: Heteroresistance refers to subpopulation-mediated differential antimicrobial susceptibility within a clonal bacterial population. Usually, it designates a resistant subpopulation identified within an isolate considered susceptible by classical antimicrobial susceptibility testing. Heteroresistance lacks a uniform microbiological definition for diagnostic laboratories, and its clinical impact remains unclear for most bacterial species.

Hand Gestures Recognition for Human-Machine Interfaces: A Low-Power Bio-Inspired Armband.

Hand gesture recognition has recently increased its popularity as Human-Machine Interface (HMI) in the biomedical field. Indeed, it can be performed involving many different non-invasive techniques, e.g.

Back to School: Italian Teachers' Perceptions of the Impact of COVID-19 on Personal and Social Well-Being and Teaching Methods.

During the COVID-19 pandemic, continuous closing and reopening of schools may have had an impact on teachers' perception of the risk of contracting SARS-CoV-2 and of the effectiveness of health measures introduced to limit the spread of the virus, with consequences on teaching methods and relational bonds within schools. By means of an online survey, we measured: teachers' stress, job-satisfaction, self-efficacy and emotions at work, risk-perception of contracting SARS-CoV-2, perception of effectiveness of health measures, teaching methods and social relationships. Participants were 2446 teachers (2142 women and 304 men) all engaged in the four educational stages.

"Let's Read Together": A Parent-Focused Intervention on Dialogic Book Reading to Improve Early Language and Literacy Skills in Preschool Children.

Many children are at risk for reading difficulties because of inadequate emergent literacy skills. It is widely accepted that development of emergent literacy skills is strictly related to children's early literacy experiences at home and school. Dialogic reading is an evidence-based intervention to promote the language skills of preschool children.

A Non-Randomized Pilot Study on the Benefits of Baby Swimming on Motor Development.

According to the concept of “embodied cognition”, motor development should not be considered distant from cognitive and language processes. Motor development is essential in the first 1000 days of life, as the child explores and learns new information from the environment. Among motor activities, baby swimming allows infants to make movements that they are not able to perform on solid ground.

Public awareness of developmental language disorder in Croatia, Italy and Slovenia.

Background: Previous research, although scarce, has indicated that the general public is still relatively unaware of developmental language disorder (DLD), one of the most common (neuro)developmental disorders. Raising awareness would increase timely involvement in intervention procedures.

Aims: To examine public awareness of DLD in the neighbouring countries of Croatia, Italy and Slovenia, as well as to assess the influence of age, gender and education level on that awareness.

A practical guide for generating unsupervised, spectrogram-based latent space representations of animal vocalizations.

The manual detection, analysis and classification of animal vocalizations in acoustic recordings is laborious and requires expert knowledge. Hence, there is a need for objective, generalizable methods that detect underlying patterns in these data, categorize sounds into distinct groups and quantify similarities between them. Among all computational methods that have been proposed to accomplish this, neighbourhood-based dimensionality reduction of spectrograms to produce a latent space representation of calls stands out for its conceptual simplicity and effectiveness.

Structure simplification of the Securinine skeleton reveals the importance of BCD ring system for the cytotoxic activity on HCT116 and HL60 cell lines.

Function-oriented molecular editing of the polycyclic scaffold of securinine led to the preparation of a library of simplified analogs that have been evaluated for their cytotoxicity potential against HCT116 and HL60 human cell lines. Chemical diversity at the C14 position (securinine numbering) was generated through the site-selective γ-iodination followed by Pd-catalyzed Sonogashira and Suzuki-Miyaura reactions. To explain the selectivity in the iodination step, a reaction mechanism has been proposed.

Characterization of Amino Acid Substitution W20S in MgrB Involved in Polymyxin Resistance in Klebsiella pneumoniae.

In the major human pathogen Klebsiella pneumoniae, MgrB inactivation by disruptive insertion sequence (IS) elements and mutations leading to early termination are known to play an important role in polymyxin resistance. In this study, we examined a collection of invasive -producing K. pneumoniae isolates belonging to the high-risk clone sequence type 258 (ST258) displaying high rates of resistance to many antimicrobials, including polymyxins.

Performance metrics for marine mammal signal detection and classification.

Automatic algorithms for the detection and classification of sound are essential to the analysis of acoustic datasets with long duration. Metrics are needed to assess the performance characteristics of these algorithms. Four metrics for performance evaluation are discussed here: receiver-operating-characteristic (ROC) curves, detection-error-trade-off (DET) curves, precision-recall (PR) curves, and cost curves.

How Does Toddlers' Engagement in Literacy Activities Influence Their Language Abilities?

The most intensive period of language development is during the first years of life, during which the brain is developing rapidly. Research has shown that children from disadvantaged households who received high-quality stimulation at a young age grew into adults who earned an average of 25% more than those who did not receive these interventions. In addition, it has been suggested that children who show a greater interest in literacy-related activities and voluntarily engage in them are likely to become better readers than children with less interest in literacy.

Distance Learning Effects Among Italian Children and Parents During COVID-19 Related School Lockdown.

During the COVID-19 pandemic, both children and their parents experienced consequences related to distance learning (DL). However, positive and negative effects have varied greatly among families, and the specific factors explaining these differences in experiences are still underexplored. In this study, we examined children's executive functions (EF) and parents' psychological well-being in relation to negative and positive effects of DL on both children and their parents.