Modulation of age-related changes in serum 1,25-dihydroxyvitamin D and parathyroid hormone by dietary restriction of Fischer 344 rats.

The purpose of this study was to determine the effect of food restriction on age-related changes in serum 1,25-dihydroxyvitamin D and PTH, two important regulators of Ca metabolism. Starting at 6 wk, male F344 rats were fed a purified diet either ad libitum (non-restricted) or 60% of ad libitum (restricted). Rats from each group were killed at 5, 13, 22 and 28 mo of age.

Chronic ethanol consumption and aging: changes in lipid composition of liver microsomes.

Both aging and chronic ethanol consumption have been found to produce changes in lipid composition. Severity of intoxication, withdrawal and release of gamma-aminobutyric acid following chronic ethanol consumption have been shown to be associated with age. It was predicted in this study that aged mice would differ in response to ethanol-induced changes in lipid composition of liver microsomes as compared to younger mice.