Publications by authors named "Robyn W Baker"
Article Synopsis
- Premature infants who are exposed to chorioamnionitis have a higher chance of developing brain issues like periventricular leukomalacia (PVL) and intraventricular hemorrhage (IVH), which may be linked to inflammation and blood flow changes in the brain.
- A study involving 49 infants showed that those exposed to chorioamnionitis had lower intermediate variability in measures of their cerebral oxygen delivery, particularly on the first day of life, which suggests a potential connection to brain injury risk.
- The research highlights the need for further investigations to understand how these changes in cerebral oxygen delivery relate to blood flow regulation and oxygen use in premature infants.
Background: In premature infants, intraventricular hemorrhage occurs more commonly in the left than the right hemisphere. We have demonstrated previously that cerebral blood flow velocity is lower in the left than the right middle cerebral artery in the first few hours after birth. This may be due to the open ductus arteriosus.
View Article and Find Full Text PDFObjective: To test the hypothesis that fetal vessel inflammation (FVI: funisitis and/or fetal vasculitis) is associated with lower blood pressure (BP) over the first week of life and an increased risk of periventricular leukomalacia (PVL) among premature infants.
Study Design: A total of 255 infants born at <1350 g to normotensive mothers were stratified by gestational age (GA) and grouped by presence/absence of FVI on placental pathology. Daily highest (Hi) and lowest (Lo) systolic BP (BP(sys)), mean BP (BP(mn)) and diastolic BP (BP(dia)) over first 7 days of life were analyzed by repeated measures ANOVA and regression analysis.
Objective: To determine the relative risk of severe intraventricular hemorrhage (IVH) between two very early indomethacin treatment strategies.
Study Design: Retrospective chart review of infants <29 weeks gestation and <1350 g who received either indomethacin prophylaxis or very early echocardiography with indomethacin treatment only if the ductus arteriosus was patent.
Results: A total of one hundred and two infants received prophylactic indomethacin (pINDO).