Publications by authors named "Robyn Strong"
Article Synopsis
- DNA methylation array profiling shows promise in classifying pediatric CNS tumors, serving as a useful complement to traditional histopathology.
- The AIM BRAIN diagnostic trial tested this technique across 11 cancer centers with 269 patient samples, achieving high classification rates (66.4% and 79.2% for two classifier versions).
- Results demonstrated excellent test reproducibility (99% concordance with another study) and highlighted the technique's ability to provide significant diagnostic insights, enhancing overall CNS tumor diagnosis.
Salivary hormone analyses provide a useful alternative to fecal and urinary hormone analyses in non-invasive studies of behavioral endocrinology. Here, we use saliva to assess cortisol levels in a wild population of spotted hyenas (Crocuta crocuta), a gregarious carnivore living in complex social groups. We first describe a novel, non-invasive method of collecting saliva from juvenile hyenas and validate a salivary cortisol assay for use in this species.
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- International data shows that participating in clinical trials can lower cancer mortality rates, yet adolescents and young adults (AYA) have low enrollment in these trials.
- A steering committee was formed to identify barriers to AYA clinical trial participation and created working groups focused on regulatory awareness, access issues, and availability of trials.
- The committee's initiatives included developing guidelines to raise regulatory awareness, streamlining access procedures for young adults to participate in pediatric trials, establishing collaboration frameworks for oncology relationships, and successfully advocating for inclusion of AYA in adult oncology trials.
Urbanization represents a dramatic form of evolutionary novelty in the landscapes inhabited by many extant animals. The Cognitive Buffer Hypothesis suggests that innovation, the process by which animals solve novel problems or use novel behaviors, may be key for many animals when adapting to novel environments. If innovation is especially beneficial in urban environments, then we would expect urban animals to be more innovative than their non-urban counterparts.
View Article and Find Full Text PDFA phase I study of panobinostat in pediatric patients with refractory solid tumors, including CNS tumors.
Cancer Chemother Pharmacol
September 2018
Purpose: This was an open label, phase I (3 + 3 design), multi-centre study evaluating panobinostat in pediatric patients with refractory solid tumors.
Methods: Primary endpoints were to establish MTD, define and describe associated toxicities, including dose limiting toxicities (DLT) and to characterize its pharmacokinetics (PK). Secondary endpoints included assessing the anti-tumour activity of panobinostat, and its biologic activity, by measuring acetylation of histones in peripheral blood mononuclear cells.
. After treatment, bone sarcoma patients carry a high chance of relapse and late effects from multimodal therapy. We hypothesize that significant variation in surveillance practice exists between pediatric medical oncology (PO) and nonpediatric medical oncology (NP) sarcoma disciplines.
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