The effects of sternal and intravenous vasopressin administration on pharmacokinetics.

Objective: Purposes of this study were to compare intravenous (IV) and sternal intraosseous (SIO) administration of vasopressin relative to concentration maximum (Cmax), time to maximum concentration (Tmax), and mean concentration in a cardiac arrest model.

Design: Prospective, between subjects, randomized experimental design.

Setting: Vivarium.