Publications by authors named "Robin Vael"
Background: There are limited data describing lung function changes in children after an asthma exacerbation. Our hypothesis was that lung function does not fully recover in children in the months following an asthma exacerbation.
Methods: We used a data set of children with asthma where lung function (including FEV , FEV /FVC ratio and FEF ) was measured at 3-month intervals over a year.
Introduction: Exhaled nitric oxide fraction ( ), a biomarker of eosinophilic airway inflammation, may be useful to guide asthma treatment. -guided treatment may be more effective in certain subgroups for improving asthma outcomes compared to standard treatment.
Methods: An individual patient data analysis was performed using data from seven randomised clinical trials (RCTs) which used to guide asthma treatment.
Introduction: Fractional exhaled nitric oxide (F NO) may be a useful objective measurement to guide asthma treatment. What remains uncertain is what change in F NO is clinically significant.
Methods: An individual patient data analysis was performed using data from seven randomized clinical trials which used F NO to guide asthma treatment.
Background: Repeated measurements of spirometry and fractional exhaled nitric oxide (Feno) are recommended as part of the management of childhood asthma, but the evidence base for such recommendations is small. We tested the hypothesis that reducing spirometric indices or increasing Feno will predict poor future asthma outcomes.
Methods: A one-stage individual patient data meta-analysis used data from seven randomized controlled trials in which Feno was used to guide asthma treatment; spirometric indices were also measured.