Publications by authors named "Robin Stelling"
Article Synopsis
- - The study explores the potential of niclosamide, a drug typically used for treating tapeworm infections, as a therapy for colorectal cancer (CRC) by targeting the Wnt/β-catenin signaling pathway.
- - Experiments showed that niclosamide effectively inhibited cell proliferation in various CRC cell lines and significantly decreased Wnt signaling activity at higher concentrations, while also downregulating certain target genes.
- - The results suggest that niclosamide disrupts the nuclear β-catenin-Bcl9-LEF/TCF complex and activates alternative signaling pathways, indicating its promise as a treatment for advanced CRC and highlighting the need for further research.
