Publications by authors named "Robin S Scott"
Background/aims: The term idiopathic short stature (ISS) describes short stature of unknown, but likely polygenic, etiology. This study aimed to identify genetic polymorphisms associated with the ISS phenotype, and with growth response to supplemental GH.
Methods: Using a case-control analysis we compared the prevalence of "tall" versus "short" alleles at 52 polymorphic loci (17 in growth-related candidate genes, 35 identified in prior genome-wide association studies of adult height) in 94 children with ISS followed in the Genetics and Neuroendocrinology of Short Stature International Study, versus 143 controls from the Fels Longitudinal Study.
Article Synopsis
- GH treatment in children has been associated with an increased risk of type 2 diabetes, suggesting that it may impair glucose metabolism.
- In a study of over 11,000 GH-treated patients, the incidence of type 2 diabetes was found to be significantly higher compared to a control group of U.S. youth.
- It is recommended that glucose levels be monitored regularly in GH-treated children, especially for those with existing risk factors for type 2 diabetes.