Publications by authors named "Robin Rohayem"
Inflammatory skin diseases such as atopic eczema (atopic dermatitis [AD]) affect children and adults globally. In AD, the skin barrier is impaired on multiple levels. Underlying factors include genetic, chemical, immunologic, and microbial components.
View Article and Find Full Text PDF[Global environmental changes and the epithelial barrier hypothesis].
Dermatologie (Heidelb)
February 2024
Article Synopsis
- The rise of noncommunicable diseases (NCDs) is linked to environmental factors that damage epithelial barriers in organs like the skin, lungs, and gut.
- The research highlights various substances, including particulate matter and detergents, that may contribute to the increase in atopic diseases through barrier damage.
- To address these health issues, the article suggests developing new prevention and treatment strategies, emphasizing the need for stricter regulation of harmful chemicals and actions against environmental pollution and climate change.
Atopic dermatitis (AD) is an inflammatory skin disease with a microbiome dysbiosis towards a high relative abundance of . However, information is missing on the actual bacterial load on AD skin, which may affect the cell number driven release of pathogenic factors. Here, we combined the relative abundance results obtained by next-generation sequencing (NGS, 16S V1-V3) with bacterial quantification by targeted qPCR (total bacterial load = 16S, = nuc gene).
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