[Protein-losing enteropathy syndrome caused by a localization of Kaposi's sarcoma in AIDS].

A 35-year-old HIV positive patient with skin and gastrointestinal localization of a Kaposi's sarcoma was admitted for severe diffuse edema. Increased alpha-I-antitrypsin clearance (150 ml/24 h) allowed us to confirm the diagnosis of protein loosing enteropathy resulting from sarcoma infiltration in the stomach, the duodenum and the entire small bowel. At autopsy, ileal ulcerations were found.

In situ detection of a heat-shock regulatory element binding protein using a soluble synthetic enhancer sequence.

In various studies, enhancer binding proteins have been successfully absorbed out by competing sequences inserted into plasmids, resulting in the inhibition of the plasmid expression. Theoretically, such a result could be achieved using synthetic enhancer sequences not inserted into plasmids. In this study, a double stranded DNA sequence corresponding to the human heat shock regulatory element was chemically synthesized.

Transpalatal approach to the petrous apex.

A case is described in which a transpalatal, transpharyngeal approach was used for access to a cyst of the petrous apex. Although its indications are limited, in selected patients this conservative procedure has advantages over the more invasive lateral routes.

Cloning and expression of a cDNA for human thioredoxin.

Thioredoxin is the best representative enzyme of a group of proteins, widely distributed and possessing dithiol-disulfide oxidoreductase activity. We have constructed a cDNA library from messenger RNAs isolated from a lymphoblastoid B cell line (Epstein-Barr virus-immortalized normal human lymphocytes). Screening of this library with synthetic oligonucleotide probes, constructed from the NH2-terminal amino acid sequence of a protein produced by this line, allowed us to identify a full-length cDNA clone coding for human thioredoxin.

Intramitochondrial factors controlling hepatic fatty acid oxidation at weaning in the rat.

Fatty acid oxidation was studied in isolated liver mitochondria of rats during the suckling-weaning transition. The oxidation rate of oleyl-CoA and palmitoylcarnitine was reduced 2.5-fold in rats weaned on a high-carbohydrate diet compared to suckling rats, when acetyl-CoA produced by beta-oxidation was directed towards ketone-body synthesis.

[Comparative serum pharmacokinetics of prednisone and prednisolone methylsulfobenzoate after oral administration].

Pharmacokinetic values of prednisone and prednisolone were measured in the serum of 6 healthy volunteers after oral administration of either prednisolone methylsulfobenzoate 30 mg or prednisone 30 mg. Peak serum concentrations of prednisolone obtained after dosing with prednisone occurred earlier and were higher (473 +/- 106 ng/ml) than those obtained after dosing with prednisolone methylsulfobenzoate (232 +/- 70 ng/ml; P less than 0.01).

Decreased hepatic fatty acid oxidation at weaning in the rat is not linked to a variation of malonyl-CoA concentration.

In rats weaned on a high-carbohydrate diet, hepatic fatty acid oxidation capacity is decreased when compared to suckling rats. Previous studies (Benito et al., 1979) suggested that a malonyl-CoA-dependent mechanism could be at the origin of this decrease.

[Limitations of scintigraphy using metaiodobenzylguanidine for locating pheochromocytomas. Apropos of 2 cases].

Two cases of MIBG (metaiodobenzylguanidine) scintigraphy are reported: the first case concerns a female patient hospitalized for high blood pressure (HBP) with symptoms evocative of pheochromocytoma. Urinary titration of catecholamines metabolites, which are usually abnormally high, and tomodensitometry permit the visualization of a left adrenal tumor. On the contrary, the MIBG scintigraphy does not show any abnormal fixation.

[Neuromuscular forms of hyperparathyroidism. Apropos of 2 cases].

The authors report two cases of hyperparathyroidism presenting mainly with muscular weakness. In the first case, a 74 year old woman had become completely bed-ridden and muscular recovery was obtained in 18 months. In the second case, a 24 year old sportsman had to stop all competition.

[Parenteral nutrition for Crohn disease in the third trimester of pregnancy. Apropos of a case].

The authors report a case of Crohn's disease in pregnancy where complications made it necessary to give the digestive system a complete rest by using parenteral nutrition. A review of the literature shows that it is possible to use this technique in pregnancy.

[Massive air loss after chest injury. Exclusion of 2 segmental bronchi without parenchymal sacrifice].

Emergency thoracotomy was performed in a case of massive air loss consecutive to a thoracic injury. Two bronchi which had ruptured were excluded by suture, which made it possible to avoid pneumonectomy. The reasons for this therapeutic attitude are detailed.

Nitrate Reduction in Roots and Shoots of Barley (Hordeum vulgare L.) and Corn (Zea mays L.) Seedlings: I. N Study.

Nitrate reduction in roots and shoots of 7-day-old barley seedlings, and 9-day-old corn seedlings was investigated. The N-depleted seedlings were transferred for 24 h or 48 h of continuous light to a mixed nitrogen medium containing both nitrate and ammonium. Total nitrate reduction was determined by (15)N incorporation from (15)NO(3) (-), translocation of reduced (15)N from the roots to the shoots was estimated with reduced (15)N from (15)NH(4) (+) assimilation as tracer, and the translocation from the shoots to the roots was measured on plants grown with a split root system.

Evidence that the development of hepatic fatty acid oxidation at birth in the rat is concomitant with an increased intramitochondrial CoA concentration.

The development of hepatic fatty acid oxidation during the perinatal period in the rat was studied using isolated mitochondria. Ketone body synthesis from substrates entering at different levels of beta-oxidation was 2-3 times lower in mitochondria isolated from term-fetal liver than in 16-h-old newborn or adult liver mitochondria. The low rate of palmitoyl-L-carnitine oxidation in term-fetal mitochondria was linked neither to the low capacity of the respiratory chain nor to the removal of acetyl-CoA in the hydroxymethylglutaryl-CoA synthase pathway.

Purification to homogeneity and NH2-terminal amino acid sequence of a novel interleukin 1 species derived from a human B cell line.

A subclone, referred to as 3B6, derived from a DR-negative EBV-transformed B cell line, has been found to spontaneously produce IL 1. 3B6-IL 1 displays a pI of 5 on FPLC chromatofocusing. It has been purified to homogeneity by a sequence of ion-exchange chromatography and affinity chromatography on procion red agarose.

Immunochemical Characterization of Nitrate Reductase Forms from Wild-Type (cv Williams) and nr(1) Mutant Soybean.

Soybean (Glycine max L. Merr.) leaves contain two forms of nitrate reductase (NR)-NAD(P)H:NR and NADH:NR.