Ex-vivo evaluation of a percutaneous looped thread desmotomy of the accessory ligament of the deep digital flexor tendon in horses.

Objective: To determine the ability to completely transect the equine accessory ligament of the deep digital flexor tendon (AL-DDFT) via an ultrasonographically-guided, percutaneous looped thread desmotomy using FiberWire suture as a cutting device.

Study Design: Ex-vivo study.

Sample Population: A total of 24 normal equine distal forelimb specimens.

Topical ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% significantly reduce corneal sensitivity without short-term negative side effects in horses.

Objective: To evaluate corneal sensitivity and acute side effects following application of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% on the healthy equine cornea.

Animals Studied: Eight healthy adult horses.

Effects of subconjunctival ropivacaine, liposomal bupivacaine, and mepivacaine on corneal sensitivity in healthy horses.

Objective: To evaluate corneal sensitivity and adverse events following subconjunctival administration of three local anesthetics in horses.

Study Design: Randomized, masked, crossover study.

Animals: Twelve healthy adult mares.

In vitro antibacterial efficacy of autologous conditioned plasma and amniotic membrane eye drops.

Objective: To determine the in vitro antibacterial efficacy of equine and canine autologous conditioned plasma (ACP) and amniotic membrane extract eye drops (AMEED) against aerobic bacteria common to the corneal surface.

Procedures: Canine (n = 4) and equine (n = 4) anticoagulated whole blood samples were sterilely collected, pooled for each species, and processed using the Arthrex ACP® Double-Syringe System. Platelet counts were performed on ACP and pooled blood.

Biomechanical Comparison of a Headless Compression Screw Fastener and AO Cortical Bone Screw for Fixation of a Simulated Equine Third Carpal Bone Slab Fracture.

Frontal plane slab fractures account for the majority of third carpal bone (C3) fractures in racing and performance horses. Recommended treatment is stabilization with a lagged AO cortical screw. Associated complications are fragment splitting, fragment spinning, and irritation of dorsal soft tissue structures.

Subconjunctival enucleation with orbital implant placement in standing horses: 20 cases (2014-2017).

Objective: To develop a protocol for subconjunctival enucleation and orbital implant placement in standing horses and to document short- and long-term complications, cosmesis, and client satisfaction.

Animals: 20 horses with nonneoplastic ocular disease requiring enucleation.

Procedures: A standardized protocol of surgical suite cleaning, patient preparation, sedation, local nerve blocks, surgical procedure, and postoperative care was performed.

Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses.

An ideal dexmedetomidine protocol has yet to be determined for standing sedation in horses. It was hypothesized that an IV bolus followed by CRI dexmedetomidine would have a quicker increase in plasma concentrations compared with repeated IM injections. In a crossover design, eight adult, female horses were randomly placed into two groups: the CRI group (IV bolus dexmedetomidine at 0.

Retrospective Evaluation of Fluoxetine Hydrochloride Use in Horses: 95 Cases (2010-2019).

This study aimed to describe the clinical use of oral fluoxetine hydrochloride administration in horses using a retrospective medical records analysis and to determine owner perception of efficacy via a standardized questionnaire. The records of ninety-five horses for which fluoxetine had been prescribed by the equine service of a veterinary teaching hospital from November 2010 and February 2019 were identified, and data were collected from the medical records. A standardized questionnaire was used to obtain data from owners regarding length of administration, ease of administration, adverse effects, and whether the owner noted improvement in the horse's behavior.

Synovial butorphanol concentrations and mechanical nociceptive thresholds after intravenous regional limb perfusion in standing sedated horses.

Objective: To determine synovial butorphanol concentrations and mechanical nociceptive threshold (MNT) changes after butorphanol intravenous regional limb perfusion (IVRLP).

Study Design: Experimental ANIMALS: Six adult horses.

Methods: Cephalic IVRLP was performed with 10 mg butorphanol in sedated horses with a wide rubber tourniquet and a total volume of 30 mL.

Plasma and synovial fluid pharmacokinetics of a single intravenous dose of meropenem in adult horses.

The objective of this study was to determine the pharmacokinetics of meropenem in horses after intravenous (IV) administration. A single IV dose of meropenem was administered to six adult horses at 10 mg/kg. Plasma and synovial fluid samples were collected for 6 hr following administration.

Meropenem synovial fluid concentrations after intravenous regional limb perfusion in standing horses.

Objective: To determine meropenem concentrations in radiocarpal (RC) joint fluid and plasma after intravenous regional limb perfusion (IVRLP).

Study Design: In vivo experimental study.

Animals: Nine healthy adult mares.

The effects of subconjunctival bupivacaine, lidocaine, and mepivacaine on corneal sensitivity in healthy horses.

Objective: To compare the efficacy and duration of effect of three local anesthetics on corneal sensitivity when administered subconjunctivally in horses.

Animals Studied: Eight healthy adult horses.

Procedure: A randomized, masked, crossover study design was used, with a two-week washout period between trials.

Effects of Firocoxib, Flunixin Meglumine, and Phenylbutazone on Platelet Function and Thromboxane Synthesis in Healthy Horses.

Objective: Determine the effects of nonsteroidal anti-inflammatory drugs (NSAID) on platelet function and thromboxane synthesis immediately after drug administration and following 5 days of NSAID administration in healthy horses.

Study Design: Randomized cross-over study.

Animals: Healthy adult horses (n=9; 6 geldings and 3 mares).

Simple tube centrifugation for processing platelet-rich plasma in the horse.

This study evaluated the quality and bacteriologic safety of platelet-rich plasma (PRP) produced by 3 simple, inexpensive tube centrifugation methods and a commercial system. Citrated equine blood collected from 26 normal horses was processed by 4 methods: blood collection tubes centrifuged at 1200 and 2000 × g, 50-mL conical tube, and a commercial system. White blood cell (WBC), red blood cell (RBC), and platelet counts and mean platelet volume (MPV) were determined for whole blood and PRP, and aerobic and anaerobic cultures were performed.