The ForeSee (4C) approach for integrative analysis in gene discovery.

The development of high-throughput experimental techniques has made measurements for virtually all kinds of cellular components possible. Effective integration and analysis of this diverged information to produce insightful knowledge is central to biological study today. In this chapter, we present a methodology for building integrative analytical workbenches using the workflow technology.

Solutions for complex, multi data type and multi tool analysis: principles and applications of using workflow and pipelining methods.

Analytical workflow technology, sometimes also called data pipelining, is the fundamental component that provides the scalable analytical middleware that can be used to enable the rapid building and deployment of an analytical application. Analytical workflows enable researchers, analysts and informaticians to integrate and access data and tools from structured and non-structured data sources so that analytics can bridge different silos of information; compose multiple analytical methods and data transformations without coding; rapidly develop applications and solutions by visually constructing analytical workflows that are easy to revise should the requirements change; access domain-specific extensions for specific projects or areas, for example, text extraction, visualisation, reporting, genetics, cheminformatics, bioinformatics and patient-based analytics; automatically deploy workflows directly into web portals and as web services to be part of a service-oriented architecture (SOA). By performing workflow building, using a middleware layer for data integration, it is a relatively simple exercise to visually design an analytical process for data analysis and then publish this as a service to a web browser.

Addressing informatics challenges in Translational Research with workflow technology.

Interest in Translational Research has been growing rapidly in recent years. In this collision of different data, technologies and cultures lie tremendous opportunities for the advancement of science and business for organisations that are able to integrate, analyse and deliver this information effectively to users. Workflow-based integration and analysis systems are becoming recognised as a fast and flexible way to build applications that are tailored to scientific areas, yet are built on a common platform.

Ab initio modelling of the N-terminal domain of the secretin receptors.

G protein coupled receptors of the secretin family are activated by peptide hormones of about 30 residues in length. There is considerable sequence homology within both the hormone and receptor families. The receptors possess in addition to the integral membrane domain a characteristic extracellular domain of about 120 residues in length, having conserved cysteine residues, which are involved in disulphide bridge formation, and tryptophanes, which have been shown to be critical for hormone binding.