Publications by authors named "Roberto Zaralli"
Article Synopsis
- The study examines the follow-up period for women aged 35-64 who test positive for high-risk HPV but have negative cytology, questioning if a 1-year follow-up is adequate.
- It was found that a significant percentage (54.5%) of these women had persistent HPV infections after 1 year, with HPV16 frequently involved, suggesting that some infections are transient.
- The findings suggest extending the follow-up period could reduce unnecessary procedures, as genotyping may help identify which infections are likely to lead to serious conditions like CIN2+ lesions.
BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma.
Appl Immunohistochem Mol Morphol
March 2015
Inhibitors of RAF inhibit the MAPK pathway that plays an important role in the development and progression of those melanoma carrying the V600E BRAF mutation, but there's a subset of such patients who do not respond to the therapy. Various mechanisms of drug resistance have been proposed which include the clonal heterogeneity of the tumor. We have studied a population of nodular melanoma to investigate the intratumor and intertumor heterogeneity by Laser Capture Microdissection (LCM) analysis.
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