Machine-Learning Assisted Optimisation of Free-Parameters of a Dual-Input Power Amplifier for Wideband Applications.

This paper presents an auto-tuning approach for dual-input power amplifiers using a combination of global optimisation search algorithms and adaptive linearisation in the optimisation of a multiple-input power amplifier. The objective is to exploit the extra degrees of freedom provided by dual-input topologies to enhance the power efficiency figures along wide signal bandwidths and high peak-to-average power ratio values, while being compliant with the linearity requirements. By using heuristic search global optimisation algorithms, such as the simulated annealing or the adaptive Lipschitz Optimisation, it is possible to find the best parameter configuration for PA biasing, signal calibration, and digital predistortion linearisation to help mitigating the inherent trade-off between linearity and power efficiency.

Bronchial malondialdehyde DNA adducts, tobacco smoking, and lung cancer.

Tobacco smoking is a major risk factor for lung cancer causing, among other effects, oxidative stress and lipid peroxidation. Malondialdehyde (MDA)-DNA adducts can be induced by direct DNA oxidation and by lipid peroxidation. We measured the relationship between bronchial MDA-DNA adducts and tobacco smoking, cancer status, and selected polymorphisms in 43 subjects undergoing a bronchoscopic examination for diagnostic purposes.

Comparison of DNA adduct levels in nasal mucosa, lymphocytes and bronchial mucosa of cigarette smokers and interaction with metabolic gene polymorphisms.

The recent introduction of biomarkers in population studies of lung cancer has improved the traditional epidemiological approach, especially in the detection of high risk groups. Many inhalable carcinogens form DNA adducts, an initial event in lung carcinogenesis, and therefore the identification of easily accessible sources of DNA for population studies is considered a leading priority in the field. In this study we compared the frequency of DNA adducts in samples from nasal brushing, bronchial biopsy and peripheral blood lymphocytes (PBL) in a group of 55 subjects, both smokers and non-smokers, undergoing bronchoscopy for diagnostic purposes.