Publications by authors named "Roberto Pozzan"
Article Synopsis
- Coronary failure is the leading cause of death globally, and the study aims to evaluate the biomarkers interleukin 18 (IL-18) and thrombus precursor protein (TpP) for early assessment of coronary artery disease (CAD).
- The research involved 119 patients divided into three groups: those with acute coronary syndrome, chronic CAD, and a control group without coronary lesions but at risk for CAD, with statistical analyses conducted to compare biomarker levels.
- Results showed significantly higher levels of IL-18 and TpP in the acute coronary syndrome group compared to the others, indicating these biomarkers may be linked to atherosclerotic plaque instability in acute phases of CAD, but not in chronic cases.
Background The role of Ser49Gly beta1-adrenergic receptor genetic polymorphism (ADBR1-GP-Ser49Gly) as a predictor of death in heart failure (HF) is not established for the Brazilian population. Objectives To evaluate the association between ADBR1-GP-Ser49Gly and clinical outcomes in individuals with HF with reduced ejection fraction. Methods Secondary analysis of medical records of 178 patients and genotypes of GPRβ1-Ser49Gly variants, classified as Ser-Ser, Ser-Gly and Gly-Gly.
View Article and Find Full Text PDFPurpose: We aimed to correlate three polymorphisms of the Hedgehog Interacting Protein () gene with the three main phenotypes of the chronic obstructive pulmonary disease (frequent exacerbator (FE), asthma/COPD overlap (ACO), and emphysema with hyperinflation).
Patients And Methods: A cross-sectional study was carried out in the Department of Pulmonology at the Rio de Janeiro State University from February 2015 to July 2018. A total of 81 patients diagnosed with COPD according to the criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) were enrolled.
Background: Systemic lupus erythematosus (SLE) is a severe autoimmune disease that involves multiple organ systems. Lupus nephritis (LN) is a complication of SLE and is associated with poor survival and high morbidity. Many genomic studies have been performed worldwide, and several histocompatibility leukocyte antigen (HLA) loci are linked to lupus susceptibility.
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- - The study investigates the relationship between ACE gene polymorphisms and clinical outcomes in heart failure patients in Rio de Janeiro, focusing on the frequency of these polymorphisms and their effects on echocardiographic measurements.
- - Among 99 patients analyzed, the DD genotype was the most prevalent, showing the highest rates of worsening heart function compared to DI and II genotypes in terms of left ventricular sizes and ejection fraction.
- - Findings suggest that patients with the DD genotype experience more significant declines in heart function over time, indicating that genetic profiling may help in stratifying risk for heart failure outcomes.
Background: Studies show an association between changes in apolipoprotein E (ApoE) and LDLR receptor with the occurrence of dyslipidemia.
Objectives: To investigate the association between polymorphisms of the APOE (ε2, ε3, ε4) and LDLR (A370T) genes with the persistence of abnormal serum lipid levels in young individuals followed up for 17 years in the Rio de Janeiro Study.
Methods: The study included 56 individuals (35 males) who underwent three assessments at different ages: A1 (mean age 13.
Background: Drug-induced increase in QT dispersion has been associated with potentially fatal ventricular arrhythmias. Little is known about the use of psychotropic substances, alone or in combination with other drugs on QT dispersion.
Objectives: To evaluate the impact of psychotropic drugs on QT interval dispersion in adults.
Background: The role of angiotensin-converting enzyme genetic polymorphisms as a predictor of echocardiographic outcomes on heart failure is yet to be established. The local profile should be identified so that the impact of those genotypes on the Brazilian population could be identified. This is the first study on exclusively non-ischemic heart failure over a follow-up longer than 5 years.
View Article and Find Full Text PDFBackground: The impact of blood pressure (BP) during adolescence on other cardiovascular risk factors in young adults is important for the primary prevention.
Objective: To evaluate BP, anthropometric indexes, metabolic and inflammatory profiles in young individuals stratified by their BP behavior recorded for 18 years.
Methods: A total of 116 individuals, of whom 63 were males, from the Rio de Janeiro study (follow-up of 17.
Background: Data on noninvasive vascular assessment and their association with cardiovascular risk variables are scarce in young individuals.
Objective: To evaluate the association between pulse wave velocity and blood pressure, anthropometric and metabolic variables, including adipocytokines, in young adults.
Methods: A total of 96 individuals aged 26 to 35 years (mean 30.
Background: Pulse wave velocity (PWV) can be a marker of cardiovascular impairment, but there are few studies in young adults.
Objective: To evaluate the association between blood pressure (BP), current anthropometric and metabolic variables and those obtained 13 years earlier, in childhood and adolescence, with PWV.
Methods: Sixty individuals were followed longitudinally and split into two groups according to the percentile of blood pressure (BP) obtained 13 years earlier: Group 1 (G1): BP percentile < 50 (n = 25, 11M, 26.
Background: The association between uric acid (UA) and cardiovascular risk variables remains a controversial issue in epidemiological studies.
Objective: To evaluate the association between UA, blood pressure (BP), anthropometric indices and metabolic variables in a non-hospitalized population stratified by UA quintiles.
Methods: A cross-sectional observational study evaluated 756 individuals (369 males), aged 50.
Background: The adoption of primary prevention measures among young people has a favorable impact on the context of cardiovascular diseases.
Objective: To assess blood pressure (BP) and cardiovascular risk variables among young adults stratified according to the body mass index (BMI) behavior obtained along 17 years, since childhood/adolescence (C/A).
Methods: Three assessments were carried out in 115 individuals pertaining to the study cohort of Rio de Janeiro, Brazil.
Studies about the impact of HDL-C levels on the incidence of cardiovascular disease (CVD) in the elderly are scarce. We decided to evaluate the relation of clinical and laboratory variables to the incidence of CVD events in the elderly stratified according to HDL-C behavior in an 8-year follow-up. We assessed 126 elderly (mean age: 70.
View Article and Find Full Text PDFBackground: The study of the cardiovascular risk variables in young populations is fundamental to establish primary prevention strategies.
Objective: To evaluate the blood pressure (BP), anthropometric and metabolic profile in young individuals from The Rio de Janeiro Study, followed by 17 years.
Methods: A total of 115 individuals (64 males) were evaluated at three different moments (follow-up: 212.
Background: Studies on the impact of HDL-c and the occurrence of cardiovascular disease (CV) in the elderly are scarce.
Objective: To evaluate the clinical and laboratory variables and the occurrence of CV events in elderly patients stratified according to the behavior of HDL-c during an eight-year follow up.
Methods: We evaluated 81 elderly patients, mean age of 68.
Objective: The objective of this study was to assess the mean intima-media thickening of carotid arteries of elderly subjects, and its relationship with age, anthropometric measurements, high systolic blood pressure and dyslipidemia.
Methods: In this investigation, 129 subjects were enrolled between 1995 and 1998, age ranging from 29 to 94 years. They were assigned to one of 4 groups, including 2 control groups (group I, of healthy younger subjects; group II of healthy elderly subjects).
Metabolic syndrome is a complex disorder associated with several cardiovascular risk factors resulting in a 2.5-fold increase in cardiovascular mortality in adults. However, over the last 20 years, the same association has been demonstrated in the young population, and it is also related to a parental history of the syndrome.
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