Rapid Domoic Acid Depuration in the Scallop and Its Transfer from the Digestive Gland to Other Organs.

Domoic acid (DA), the main toxin responsible for Amnesic Shellfish Poisoning, frequently affects the marine resources of Chile and other countries across the South Pacific, thus becoming a risk for human health. One of the affected resources is the scallop . Even though this species has a high commercial importance in Northern Chile and Peru, the characteristics of its DA depuration are not known.

Paralytic Shellfish Toxins in Surf Clams during a Large Bloom of Dinoflagellates Associated to an Intense Shellfish Mass Mortality.

In late February 2016, a harmful algal bloom (HAB) of was detected in southern Chiloé, leading to the banning of shellfish harvesting in an extended geographical area (~500 km). On April 24, 2016, this bloom produced a massive beaching (an accumulation on the beach surface of dead or impaired organisms which were drifted ashore) of surf clams in Cucao Bay, Chiloé. To determine the effect of paralytic shellfish poisoning (PSP) toxins in , samples were taken from Cucao during the third massive beaching detected on May 3, 2016.

Does recombinant human interleukin-11 exert direct electrophysiologic effects on single human atrial myocytes?

Recombinant human interleukin-11 (rhIL-11) treatment given to alleviate side effects of cancer therapy is associated with an increased susceptibility to atrial arrhythmias in elderly patients. To elucidate the mechanism underlying this action, we investigated the direct electrophysiologic effect of rhIL-11 on single human atrial myocytes (HuAM) using the patch-clamp technique. Action potentials (AP) at different driving rates were recorded in the perforated-patch configuration, and L-type calcium current (I(Ca,L)), outward potassium currents (I(to) and I(K)), and the hyperpolarization-activated pacemaker current If were measured in the disrupted whole-cell configuration.