Publications by authors named "Roberto Pietri"
The introduction of self-sampling in cervical cancer screening has raised the importance of HPV test validation on self-collected samples. This study aimed to evaluate the clinical accuracy of the OncoPredict HPV Screening (SCR) assay on self-collected vaginal and first-void urine (FVU) samples, relative to cervical specimens, using the VALHUDES Framework. FVU and vaginal self-samples followed by a clinician-collected cervical brushing were collected from 500 women referred to colposcopy and tested using OncoPredict HPV SCR assay.
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- The VALHUDES initiative aimed to evaluate the effectiveness of self-collected urine and vaginal samples for detecting cervical precancers compared to traditional clinician-collected cervical samples using the OncoPredict HPV Quantitative Typing assay.
- A study involving 490 women showed that the clinical sensitivity for detecting cervical intraepithelial neoplasia (CIN2+) was comparable between self-collected samples and cervical samples, but specificity was lower for both self-collection methods.
- After optimizing the testing criteria, the OncoPredict HPV QT assay showed similar accuracy in diagnosing cervical precancers from self-collected samples as from clinician-collected cervical samples.
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- Current multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are advancing with the gravitational wave observatories ALIGO, AdVirgo, and KAGRA during their fourth observing run (O4).
- To enhance the search, the study utilized simulated binary populations and conducted a mock data challenge (MDC), optimizing the software used for real-time data analysis and alert generation.
- The paper reports on the low-latency infrastructure performance, with a median alert time of approximately 29.5 seconds for full searches, and emphasizes the importance of early warnings for neutron star mergers with a new trigger system, aiming for responses about 3.1 seconds before mergers occur.
Unlabelled: This study assessed the accuracy of high-risk human papillomavirus testing of BD Onclarity HPV (Onclarity) assay on vaginal self-collected FLOQSwab versus cervical samples to ensure similar accuracy to detect cervical intraepithelial neoplasia. Testing was performed on two automated platforms, BD Viper LT and BD COR, to evaluate the effect of machine and using two vaginal self-samples to analyze the influence of collection, transport, and freezing-unfreezing on the results. A cervical sample and two self-samples were collected from 300 women.
View Article and Find Full Text PDFThe assessment of human papillomavirus (HPV) genotype dynamics could support the adoption of more tailored preventive actions against cervical cancer. The aim of the study was to describe the prevalence of HPV infection, HPV genotype distribution, and the epidemiological characteristics of women with ASC-US cytology since the introduction of HPV-DNA testing in Sardinia (Italy), (March 2016-December 2020). Specimens were tested by RT-PCR for 14 high-risk HPV genotypes.
View Article and Find Full Text PDFWe present the first very long-term simulations (extending up to ∼140 ms after merger) of binary neutron star mergers with piecewise polytropic equations of state and in full general relativity. Our simulations reveal that, at a time of 30-50 ms after merger, parts of the star become convectively unstable, which triggers the excitation of inertial modes. The excited inertial modes are sustained up to several tens of milliseconds and are potentially observable by the planned third-generation gravitational-wave detectors at frequencies of a few kilohertz.
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