Publications by authors named "Roberto Pereira da Costa"
Article Synopsis
- Interstitial lung disease (ILD) is prevalent in rheumatoid arthritis (RA) and linked to higher mortality; this study assesses antifibrotics nintedanib and pirfenidone's real-world effectiveness and safety in RA-ILD patients.
- A multicenter observational study included 40 RA-ILD patients, primarily treated with nintedanib; data on demographics, pulmonary function tests (PFTs), and adverse events (AEs) were collected and analyzed.
- Results showed that antifibrotics halted the decline in forced vital capacity (FVC) and total lung capacity (TLC) after initiation, but diffusion capacity continued to decline, with 40% of patients experiencing adverse events.
VEXAS syndrome is a recently described autoinflammatory syndrome caused by the somatic acquisition of mutations in myeloid precursors and is frequently associated with hematologic malignancies, chiefly myelodysplastic syndromes. Disease presentation can mimic several rheumatologic disorders, delaying the diagnosis. We describe a case of atypical presentation resembling late-onset axial spondylarthritis, later progressing to a systemic inflammatory syndrome with chondritis, cutaneous vasculitis, and transfusion-dependent anemia, requiring high doses of steroids.
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