Publications by authors named "Roberto Messora"

Aims: An increase in right atrial pressure is a common feature of acute decompensated heart failure (ADHF). Such increased pressure leads to persistent kidney congestion. A marker to guide optimal diuretic therapy is missing.

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Background: The aim of this study was to investigate the effects of vitamin D (VD) on the interaction among functional, echocardiographic and hormonal parameters in patients with heart failure (HF) and VD deficiency.

Methods: In a randomized, double blind trial, 35 patients with HF and VD<20 ng/mL, received either 300,000 U of oral cholecalciferol followed by 50,000 U/month for 6 months, or placebo treatment.

Results: Changes in the 6 Minute Walking Test (6MWT) assessed at 3 and 6 months in treatment group was the primary end point.

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Objectives: To evaluate if screening and treatment of asymptomatic coronary artery disease (CAD) are effective in preventing first cardiac event in diabetics.

Methods: Diabetic patients without known CAD were randomly assigned to undergo a screening for silent myocardial ischemia followed by revascularization or to continue follow-up. The reduction of cardiac death (CD) or nonfatal myocardial infarction (MI) represented the primary aim; secondary aim was the prevention of heart failure (HF).

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Article Synopsis
  • The study aims to evaluate the effectiveness of screening asymptomatic diabetic patients for coronary artery disease (CAD) and the benefits of revascularization in those identified as high-risk.
  • Diabetic patients will be screened at outpatient services, with participants randomized into two groups: one undergoing exercise tolerance testing and the other receiving standard care.
  • Findings will inform prevention strategies for high-risk diabetic patients and assess the feasibility of implementing this screening approach in real-world settings.
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