Publications by authors named "Roberto Leo"

Article Synopsis
  • - Pregnancy significantly increases the risk of arrhythmias, which are the most common cardiovascular issues during this time, potentially causing worsening of existing conditions or presenting new ones.
  • - Key factors contributing to these heart rhythm problems include stretching of the heart muscles and heightened sympathetic nervous system activity, which can lead to severe outcomes like fainting or sudden cardiac death.
  • - Managing arrhythmias effectively requires a coordinated care approach throughout pregnancy, with careful consideration of medication effects on both the mother and fetus, while electric cardioversion is recognized as a safe treatment option for unstable patients.
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Elderly patients, when they present to the emergency department (ED) or are admitted to the hospital, are at higher risk of adverse outcomes such as higher mortality and longer hospital stays. This is mainly due to their age and their increased fragility. In order to minimize this already increased risk, adequate triage is of foremost importance for fragile geriatric (>75 years old) patients who present to the ED.

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A novel non invasive technique and a suitable apparatus for disinfestation of artworks is introduced. Non destructive and non invasive techniques are often irreplaceable in order to preserve and restore cultural heritage objects in its structure and shape. Although many techniques are available for art and archaeological works the non invasive methods are preferred as they leave the object untouched after treatment.

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The aim of the paper is the development of an accurate numerical model to compute the current density flowing through the heart of a virtual human body, and induced by an external electric or magnetic excitation. The model has been experimentally validated and then applied to investigate the main characteristics of the heart magnetic stimulation. This has been carried out by comparing the current density induced in the cardiac region by an external magnetic pulse with the corresponding quantity due to the more traditional electric source.

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Wood packaging represents a pathway for the introduction and spread of pests. In March 2002, the Food and Agriculture Organization (F.A.

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Introduction: Atrial fibrillation (AF) and diabetes mellitus type 2 (DM2) often coexist; however, a small number of patients with DM2 undergoing catheter ablation (CA) of AF have been included in previous studies. The aim of this study was to evaluate safety and efficacy of ablation therapy in DM2 patients with drug refractory AF.

Methods And Results: From January 2005 to September 2006, 70 patients with a diagnosis of DM2 and paroxysmal (n = 29) or persistent (n = 41) AF were randomized to receive either pulmonary vein isolation or a new antiarrhythmic drug treatment (ADT) with a 1-year follow-up.

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During the last 50 years, many studies have analysed the correlations between personality factors, behavioural pattern, personality type, psychiatric disorders and coronary artery disease (CAD). Although consistent evidence of causal association between CAD and major depressive disorders does exist, the role and importance of personality factors and character traits in CAD development and manifestations are still debatable. We reported the most important studies from the literature on type A behaviour pattern (TABP), the first correlated to CAD.

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Aims: Women have an increased risk for atrial fibrillation (AF)-related complications and there is evidence towards a reduced efficacy of the rhythm control strategy than men. A catheter-based strategy is therefore widely attractive, but the impact of gender on catheter ablation (CA) of AF remains undefined.

Methods And Results: We included 221 consecutive patients (150 men) who underwent CA of drug-refractory AF.

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Composite model for DNA torsion dynamics.

Phys Rev E Stat Nonlin Soft Matter Phys

February 2007

DNA torsion dynamics is essential in the transcription process; a simple model for it, in reasonable agreement with experimental observations, has been proposed by Yakushevich (Y) and developed by several authors; in this, the nucleotides (the DNA subunits made of a sugar-phosphate group and the attached nitrogen base) are described by a single degree of freedom. In this paper we propose and investigate, both analytically and numerically, a "composite" version of the Y model, in which the sugar-phosphate group and the base are described by separate degrees of freedom. The model proposed here contains as a particular case the Y model and shares with it many features and results, but represents an improvement from both the conceptual and the phenomenological point of view.

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Endothelial dysfunction, insulin resistance, and elevated levels of circulating proinflammatory markers are among the earliest detectable abnormalities in people at risk for atherosclerosis. Accelerated atherosclerosis is a leading contributor to morbidity and mortality in type 2 diabetes mellitus, a complex genetic disorder. Therefore, we hypothesized that normoglycemic offspring of patients with type 2 diabetes mellitus (NOPD) may have impaired vascular and metabolic function related to an enhanced proinflammatory state.

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Approximately 50% of all acute coronary syndromes occur in previously asymptomatic patients. This study evaluated the value of multislice computed tomography for early detection of significant coronary artery disease (CAD) in high-risk asymptomatic subjects. One hundred sixty-eight asymptomatic subjects with >or=1 major risk factor (hypertension, diabetes, hypercholesterolemia, family history, or smoking) and an inconclusive or unfeasible noninvasive stress test result (stress electrocardiography, echocardiography, or nuclear scintigraphy) were evaluated in an outpatient setting.

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Article Synopsis
  • Major depressive disorder (MDD) is linked to low-grade inflammation and increased risk of coronary artery disease, with soluble CD40 ligand (sCD40L) potentially connecting inflammation to a prothrombotic state.
  • In a study, MDD patients showed elevated levels of inflammatory and clotting markers compared to healthy controls, and active treatment with selective serotonin reuptake inhibitors (SSRIs) led to improvements in mood and reductions in these markers.
  • The findings suggest that targeting the CD40/CD40L pathway in MDD could help decrease both inflammation and the associated risk of thrombosis, indicating a possible benefit of SSRI therapy in this context.
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The presence of an abnormally short QT interval has been noted among survivors of idiopathic ventricular fibrillation and among close relatives of victims of unexplained sudden death. Most reported cases have had rate-corrected QT (QTc) intervals of <300 ms. The prevalence of such values in the community has not been documented.

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Adiponectin is the most abundant adipose-derived plasma protein. Recently adiponectin levels have been linked to most variables of metabolic syndrome and conventional risk factors for cardiovascular disease. However, its relation with major depression is yet unclear.

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The present study was designed to investigate the relations between plasma ghrelin concentrations, eating patterns, and circulating concentrations of cortisol and thyroid hormones in women with anorexia nervosa, bulimia nervosa, and binge-eating disorder. The patterns of disordered eating behavior were assessed using the Eating Attitudes Test (EAT-26) and the Bulimia Test-Revised (BULIT-R). In women with eating disorders, but not in healthy control women, plasma ghrelin concentrations were negatively correlated with body mass index (BMI) and plasma concentrations of thyreotropin (TSH), free T3 and free T4, and positively correlated with plasma concentrations of cortisol.

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