Publications by Roberto Gastelum-Garibaldi

Publications by authors named "Roberto Gastelum-Garibaldi"

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Electro-steric opening of the CLC-2 chloride channel gate.

José J De Jesús-Pérez G Arlette Méndez-Maldonado Ana E López-Romero David Esparza-Jasso Irma L González-Hernández

Sci Rep

June 2021

The widely expressed two-pore homodimeric inward rectifier CLC-2 chloride channel regulates transepithelial chloride transport, extracellular chloride homeostasis, and neuronal excitability. Each pore is independently gated at hyperpolarized voltages by a conserved pore glutamate. Presumably, exiting chloride ions push glutamate outwardly while external protonation stabilizes it.

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