Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma.

Context: p53, c-erbB-2 and epidermal growth factor receptor (EGFR) are cancer-related proteins that are usually expressed in head and neck squamous cell carcinoma (SCC). Their prognostic value remains controversial.

Objective: To evaluate the prognostic impact of p53, c-erbB-2 and EGFR expression in head and neck SCC.

Laryngeal sensitivity evaluation and dysphagia: Hospital Sírio-Libanês experience.

Context: Laryngeal sensitivity is important in the coordination of swallowing coordination and avoidance of aspiration.

Objective: To briefly review the physiology of swallowing and report on our experience with laryngeal sensitivity evaluation among patients presenting dysphagia.

Type Of Study: Prospective.

Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas.

c-myc and p53 genes were frequently deregulated in head and neck squamous cell carcinoma (HNSCC). To determine if the concomitant expression of the two oncogenes might have prognostic value, the survival and free disease time of 140 consecutive HNSCC patients followed up for a median time of 29.9 months was analyzed in the light of p53 and c-myc expression assessed by immunohistochemistry.