Natriuretic effect of 4',5-dihydroxy-6,7-methylenedioxyflavonol-3--α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside from and studies.

Aqueous leaf extracts of are widely used because of their diuretic, natriuretic, antiurolithiatic, anti-inflammatory and antihypertensive properties. The major component of the extract is the flavonoid 4',5-dihydroxy-6,7-methylenedioxyflavonol-3--α-L-rhamnopyranosyl-(1→2)-β-D-xylopyranoside, but it is not known if this compound is responsible for the biological activity. The objective of this work is to develop effective tools that allow predicting the possible activity of the flavonoid aglycone as an inhibitor of metalloproteases that regulate renal fluid excretion.