Publications by authors named "Roberto DI Carlo"
Background: The aim of the present study was to investigate how the organisation of healthcare activity during the first wave of the SARS-CoV-2 pandemic affected the timing of diagnosis of oral carcinoma in the Functional Head and Neck Department of Padua (Italy). This study gives an effective temporal dimension of the diagnostic delay that occurred during the pandemic, compared with data from the literature.
Methods: A retrospective analysis of the diagnostic path of a patient affected by oral cancer during COVID-19 pandemic was performed.
Objective: The prognostic significance of the resection margins is still subject of conflicting opinions. The purpose of this paper is to report the results of a study on the margins in carcinoma of the oral cavity, oro-hypopharynx and larynx.
Methods: A multicentre prospective study was carried out between 2015 and 2018 with the participation of 10 Italian reference hospitals.
Objective: To date, no useful prognostic biomarker exists for patients with oral squamous cell carcinoma (OCSCC), a tumour with uncertain biological behaviour and subsequent unpredictable clinical course. We aim to investigate the prognostic significance of two recurrent somatic mutations (-124 C>T and -146 C>T) within the promoter of telomerase reverse transcriptase () gene and the impact of TERT single nucleotide polymorphism (SNP) rs2853669 in patients surgically treated for OCSCC.
Methods: The genetic frequencies of rs2853669, -124 C>T and -146 C>T as well as the telomere length were investigated in 144 tumours and 57 normal adjacent mucosal (AM) specimens from OCSCC patients.
Purpose: The aim of this study is to evaluate the prognostic value of pre-treatment advanced lung cancer inflammation index (ALI) in patients with HPV-negative HNSCC undergoing up-front surgical treatment.
Methods: The present multi-centre, retrospective study was performed in a consecutive cohort of patients who underwent upfront surgery with or without adjuvant (chemo)-radiotherapy for head and neck squamous cell carcinoma (HNSCC). Patients were stratified by ALI, and survival outcomes were compared between groups.
Article Synopsis
- The study aims to assess the effectiveness of contrast-enhanced MRI and integrated [F]FDG PET/MRI in detecting lymph node metastases in head and neck squamous cell carcinoma (HNSCC) patients, using histopathology as the gold standard.
- A retrospective review of 26 patients revealed that integrated PET/MRI had higher sensitivity and accuracy compared to traditional MRI methods, particularly in identifying malignant lymph nodes.
- The findings suggest that combining PET and MRI techniques significantly enhances diagnostic accuracy, making it a better option for detecting metastatic lymph nodes in HNSCC compared to using MRI alone.
Objective: We evaluated the safety of REPLICA, a CAD/CAM-designed patient-specific titanium mandible, in patients with mandibular defects not suitable for reconstruction with traditional techniques.
Patients And Methods: We performed a cohort study with a composite primary outcome assigned at the end of a 1-year follow-up. The outcome was assigned in the presence of all the following: 1) absence of intraoral or skin extrusion of REPLICA; 2) decrease or cessation of oral pain; 3) stability or increase in mouth opening; 4) resumption of oral feeding without the need of nasogastric tube; 5) absence of fracture at multidetector computer tomography (MDCT); 6) absence of displacement (MDCT); 7) absence of screw loosening (MDCT).
Article Synopsis
- - The study explored the relationship between programmed death-ligand 1 (PD-L1) expression, immune microenvironment factors, and outcomes in laryngeal carcinoma patients receiving postoperative radiotherapy (PORT).
- - Results indicated that higher PD-L1 expression (CPS ≥ 1) was linked to lower recurrence rates and better disease-free survival compared to lower expression levels.
- - Two distinct patient clusters were identified based on immune markers, suggesting that evaluating PD-L1 and related factors can help identify patients at higher risk of cancer recurrence, potentially guiding further treatment options.
Aim: The novel primary end-point of the present study was to ascertain β-arrestin-1 expression in a cohort of consecutive patients with laryngeal squamous cell carcinoma (LSCC) with information available on their cigarette-smoking habits. A secondary end-point was to conduct a preliminary clinical and pathological investigation into the possible role of β-arrestin-1 in the epithelial-to-mesenchymal transition (EMT), identified by testing for E-cadherin, Zeb1, and Zeb2 expression, in the setting of LSCC.
Methods: The expression of β-arrestin-1, E-cadherin, zeb1, and zeb2 was ascertained in 20 consecutive LSCCs.
Background: When advanced, oral squamous cell carcinoma (OSCC) may involve adjacent non-epithelial structures, and the prognosis is worse for bone invasion. Human relaxin-2 is a peptide hormone that has recently been associated with cancer. It can induce human osteoclast differentiation and activation, suggesting a role in tumor-driven osteolysis.
View Article and Find Full Text PDFParotid localized Castleman's disease and HHV-8 infection: a case report.
Eur Arch Otorhinolaryngol
March 2008
Castleman's disease (CD) is an unusual massive proliferation of lymphoid tissue distinct in two clinical forms, localized and multicentric. The multicentric form has been related to human herpesvirus 8 (HHV-8), especially in HIV-infected patients, whereas the localized form of CD is still unrelated to viral pathogens. We report a case of a HIV-negative 16-year-old male referred to our hospital with a 12-month history of a painless swelling in his right parotid region.
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