Publications by authors named "Roberto Boccacci"
Burkitt lymphoma (BL) is characterized by a tumor microenvironment (TME) in which macrophages represent the main component, determining a distinct histological appearance known as "starry sky" pattern. However, in some instances, BL may exhibit a granulomatous reaction that has been previously linked to favorable prognosis and spontaneous regression. The aim of our study was to deeply characterize the immune landscape of 7 cases of Epstein-Barr virus-positive (EBV+) BL with granulomatous reaction compared with 8 cases of EBV+ BL and 8 EBV-negative (EBV-) BL, both with typical starry sky pattern, by Gene expression profiling performed on the NanoString nCounter platform.
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- SRY-related HMG-box gene 11 (SOX11) is overexpressed in certain types of lymphomas but absent in normal B cells, playing an oncogenic role in mantle cell lymphoma (MCL) while its role in Burkitt lymphoma (BL) is still unclear.
- In EBV-negative BL cases, SOX11 expression is linked to specific genetic changes, such as IG∷MYC translocations, indicating an alternative pathogenic mechanism compared to SOX11-negative tumors.
- Bladder cancer with SOX11 expression shows unique genetic mutations and a different cell behavior pattern, highlighting two subsets of EBV-negative BL cases based on SOX11 presence and suggesting SOX11's involvement in the early development