THE RELATIONSHIP BETWEEN CHOLESTEROL LEVELS AND THYROID EYE DISEASE.

Background: Thyroid eye disease (TED) is the most prevalent extrathyroidal manifestation of Graves' disease (GD). Emerging evidence suggests a relationship between elevated total and LDL cholesterol levels and TED. This study aimed to investigate this correlation in the Brazilian population by analyzing data from two tertiary care centers.

The polymorphic inheritance of rs225014 may predict body weight variation after Graves' disease treatment.

Objective: We aimed to investigate the role of polymorphisms rs225014 and rs12885300 in Graves' disease patients, mainly for controlling body weight following treatment.

Methods: We genotyped 280 GD patients by the time of diagnosis and 297 healthy control individuals using a TaqMan SNP Genotyping technique. We followed up 141 patients for 18.

Polymorphisms of the genes CTLA4, PTPN22, CD40, and PPARG and their roles in Graves' disease: susceptibility and clinical features.

Purpose: CTLA4, PTPN22, and CD40 are immune-regulatory genes strongly associated with GD, as well as PPARG, but their clinical significance in different populations is still uncertain.

Methods: We genotyped 282 Brazilian GD patients (234 women and 48 men, 39.80 ± 11.