Publications by authors named "Roberta Tancredi Francesco Dos Santos"
Effects of Mlx-8, a phospholipase A from Brazilian coralsnake venom, on muscarinic acetylcholine receptors in rat hippocampus.
Roberta Tancredi Francesco Dos Santos Marcelo Florencio Passos Silva Rafael Marques Porto Ivo Lebrun Luís Roberto de Camargo Gonçalves
J Venom Anim Toxins Incl Trop Dis
January 2020
Background: Here, we described the presence of a neurotoxin with phospholipase A activity isolated from venom (Mlx-8) with affinity for muscarinic acetylcholine receptors (mAChRs).
Methods: The purification, molecular mass determination, partial amino acid sequencing, phospholipase A activity determination, inhibition of the binding of the selective muscarinic ligand [H]QNB and inhibition of the total [H]inositol phosphate accumulation in rat hippocampus of the Mlx-8 were determined.
Results: Thirty-one fractions were collected from HPLC chromatography, and the Mlx-8 toxin was used in this work.