Publications by authors named "Roberta Sbrocchi"
Article Synopsis
- Effective secondary responses in CD8 T cells, which are crucial for long-lasting immunity against viruses and tumors, can vary depending on the timing of antigen exposure.
- In a study using a mouse model, researchers found that boosting CD8 T cell responses 100 days after the initial priming was more effective than boosting at 30 days, indicated by better functionality in various immune organs.
- RNA sequencing revealed that CD8 T cells at 100 days post-priming had a quiescent but responsive state, suggesting adjustments in vaccination timing could enhance the secondary immune response.
Rabies, caused by RNA viruses in the Genus Lyssavirus, is the most fatal of all infectious diseases. This neglected zoonosis remains a major public health problem in developing countries, causing the death of an estimated 25,000-159,000 people each year, with more than half of them in children. The high incidence of human rabies in spite of effective vaccines is mainly linked to the lack of compliance with the complicated administration schedule, inadequacies of the community public health system for local administration by the parenteral route and the overall costs of the vaccine.
View Article and Find Full Text PDFNearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically distinct chimpanzee adenovirus (ChAd3, ChAd63) vector priming followed by modified vaccinia Ankara (MVA) boosts, for simultaneous delivery of HCV non-structural (NSmut) and HIV-1 conserved (HIVconsv) region immunogens.
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