Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults.

Objectives:: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events.

Methods:: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA).

Habitual dietary intake and mediators of the inflammaging process in Brazilian older women.

Aim: This study aimed to assess whether the habitual intake of macronutrients by older women associates with circulating levels of important inflammaging mediators by means of a cross-sectional design with 229 Brazilian elderly women.

Methods: Laboratory tests determined serum IL1α, IL1β, IL6, IL8, IL10, IL12 and TNFα by specific immunoassays. Food records of three alternate days were decomposed into usual intake of carbohydrates, proteins and lipids (and fractions), as well as total energy value (TEV) per patient.

Pro-inflammatory cytokines correlate with classical risk factors for atherosclerosis in the admixed Brazilian older women.

Aim: Measurement of inflammatory markers for risk stratification of vascular disorders has been the focus of numerous investigations worldwide, and usually reveals augmented levels of circulating cytokines/chemokines among carriers of classic risk factors for atherosclerosis. Nonetheless, this low-grade inflammatory milieu detected in aged individuals tends to be influenced by body composition. Moreover, cardiovascular risk factors have a complex genetic etiology, and disregarding the genetic heritage may produce spurious results owing to interethnic differences.

Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women.

The prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers.

Usual dietary intake and cardiovascular risk factors in older Brazilian women.

Aim: To evaluate habitual macronutrient intake and its association with common cardiovascular risk factors in Brazilian elderly women.

Methods: Analytical cross-sectional study with 293 subjects. Carbohydrate, protein and lipid intakes were determined based on a non-consecutive three-day dietary record.